10 Benefits of Reishi spore oil

Reishi spore oil is a concentrated supplement form of reishi mushroom (Ganoderma lucidum), it is extracted by Super Critical Carbon Dioxide Fluid, SCFE-CO2. No heat, no organic solvent used, so the oil from the reishi sporocarp keeps all ingredients natural and unchanged.

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Chemical properties & pharmacological effects of Neferine

Abstract

Neferine is a natural bisbenzylisoquinoline alkaloid, mainly extracted from plants of the Nelumbo family (such as lotus seed embryo). In recent years, its wide range of biological activities (such as cardiovascular protection, anti-tumor, antioxidant, etc.) has attracted the attention of researchers. This paper reviews its chemical structure, pharmacological mechanism and potential applications, and looks forward to future research directions.

1. Introduction

Neferine has a long history in traditional medicine. Lotus seed heart (embryo) is recorded in the Compendium of Materia Medica as a medicinal material for clearing heat, calming the nerves and lowering blood pressure. As one of the main active ingredients of lotus seed heart, neferine exhibits diverse biological activities due to its unique bisbenzylisoquinoline structure. With the rise of natural product research, the pharmacological potential of neferine has gradually been revealed.

2. Chemical properties

Methyl neferine (C₃₈H₄₄N₂O₆, CAS number: 2292-16-2) belongs to the bis-benzylisoquinoline alkaloids, which are composed of two benzylisoquinoline units connected by ether bonds (Figure 1). It has a large molecular weight (624.77 g/mol) and high lipid solubility. It can be separated and purified from lotus seed germ by high performance liquid chromatography (HPLC) or mass spectrometry.

3. Pharmacological effects and mechanisms

3.1 Cardiovascular system protection

1. Anti-arrhythmic: By inhibiting the L-type calcium channel (LTCC) and delayed rectifier potassium channel (IK) of myocardial cells, it regulates the action potential duration and reduces the risk of arrhythmia.

2. Anti-hypertension and vasodilation: It activates the nitric oxide (NO) signaling pathway, promotes the release of NO by endothelial cells, and leads to relaxation of vascular smooth muscle.

3. Anti-thrombosis: Inhibits platelet aggregation induced by platelet activating factor (PAF) and reduces the risk of thrombosis.

3.2 Antioxidant and anti-inflammatory

- Scavenges free radicals: Neutralizes reactive oxygen species (ROS) through phenolic hydroxyl structure and reduces oxidative stress damage.

- Inhibits inflammatory factors: Downregulates NF-κB pathway, reduces the release of pro-inflammatory factors such as TNF-α and IL-6, and shows protective effects in acute lung injury models.

3.3 Anti-tumor activity

- Induce apoptosis: Activates mitochondrial apoptosis pathway (such as Bax/Bcl-2 imbalance, caspase-3 activation), inhibits breast cancer MCF-7 cell proliferation.

- Inhibits metastasis: Inhibits lung cancer A549 cell invasion and migration by blocking PI3K/Akt/mTOR pathway.

3.4 Neuroprotective effect

- Anti-Alzheimer's disease (AD): Reduce β-amyloid protein (Aβ) deposition, inhibit tau protein hyperphosphorylation, and improve cognitive dysfunction in mice.

4. Applications and challenges

4.1 Traditional and modern applications

- Traditional Chinese medicine uses: Lotus seeds are used to make tea to reduce internal heat and calm the nerves.

- Modern drug development: As a lead compound, explore the application of its derivatives in anti-tumor or cardiovascular diseases.

4.2 Safety and limitations

- Toxicity: Animal experiments show low acute toxicity (LD₅₀ > 2 g/kg), but long-term use may affect liver and kidney function.

- Bioavailability: High lipid solubility but poor water solubility, and the absorption rate needs to be improved through nanoformulation or structural modification.

5. Future research directions

1. Clinical transformation: Promote clinical trials to verify its efficacy on human diseases (such as hypertension and cancer).

2. Structural optimization: Enhance targeting and reduce side effects through chemical modification.

3. Multi-omics research: Combine metabolomics and proteomics to analyze its multi-target mechanism of action.

6. Conclusion

As a natural active molecule, neferine has multi-target and multi-pathway pharmacological properties and has significant potential in the treatment of cardiovascular diseases, tumors and neurodegenerative diseases. In the future, it is necessary to strengthen the connection between basic and clinical research and promote its application from laboratory to clinical application.

References ：

1. Deng Y, et al. *Neferine inhibits colorectal cancer cell growth through ROS-mediated PI3K/Akt pathway*. Cancer Lett. 2019.

Liu CM, et al. *Neferine induces apoptosis by modulating Bcl-2 family proteins in human breast cancer cells*. Phytomedicine. 2020.

3. Chinese Pharmacopoeia Commission. *Pharmacopoeia of the People’s Republic of China*. 2020 Edition. article from:Chemical properties & pharmacological effects of Neferine - Kingherbs

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What is Ivy Extract？What is ivy extract good for?

Ivy Extract is most widely used as a natural adjuvant treatment for respiratory tract congestion. It is a respiratory catarrh used for symptomatic treatment of chronic inflammatory bronchial conditions. Ivy contains hederacosides which appear to be responsible for preventing spasms in the bronchial area. It has been found the ivy leaf extract helps to increase oxygen in the lungs, and is an effective anti-inflammatory for bronchial conditions such as asthma and bronchitis.

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💧 Bilberry Extract dissolution experiment Witness the excellent water solubility of Bilberry Extract! Transparent dissolution, no residue, allowing the natural essence to be better absorbed💙👇

Kingherbs specializes in offering a diverse range of pure and natural herb powders, perfectly suited for dietary supplements and health prod

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There are many plants in nature, which play a good role in the growth and development of animals. Macleaya Cordata Extract can be used in feed products to regulate the stomach and intestines of animals. Eucommia Leaf Extract can be used in poultry breeding, increase the laying rate of laying hens, improve eggshell quality and egg quality. Reduce the content of total cholesterol in eggs and increase the content of calcium in eggs.

Animal Health Plant Extracts Raw Material Supplier — Kingherbs

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Cosmetics

The plant extracts used in cosmetics have moisturizing, whitening, lightening spots, removing wrinkles and antioxidant properties. It's also effective in skin health. For example: the Gotu Kola Extract can significantly promote the synthesis of fibroblasts and collagen, and has obvious moisturizing effect. White Peony Extract can be used as the main ingredient in cosmetics to relieve skin problems caused by hyperpigmentation.

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Herb Powder

As a professional herb and fruit powder provider, KINGHERBS excels in delivering top-quality Spray-drying, Freeze-drying, and Air-drying fruit and herb powders. Our products are distinguished by their excellent flow and solubility characteristics, making them ideal for a variety of applications. To learn more about our commitment to quality and innovation, visit our 'About Us' page.

Apocynum Venetum Powder

Asparagus Shoot Powder

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Pomegranate Powder

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Pumpkin Powder

Radix Saposhnikoviae Powder

Red Yeast Rice Powder

Rhizoma Gastrodiae Powder

White Mulberry Root Bark Powder

Wild Cherry Bark Powder

Zhejiang Fritillary Bulb Powder

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Watermelon powder

Watermelon fruit powder is made of watermelon juice by spray drying, because of cool, refreshing, sweet and juicy taste, it is a good summer fruit which is called the "king of summer". Watermelon is not only fat and cholesterol free, but also contains a lot of glucose, malic acid, fructose, protein amino acids, lycopene, etc. Watermelon powder is rich in vitamins and trace elements, it is a kind of fruit powder with high nutritional value.

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Pumpkin Seed Oil-kingherbs

Pumpkin seed oil also contains an active biocatalyst component called male hormone, which can eliminate the initial swelling of the prostate, and has a good therapeutic and preventive effect on the urinary system and prostate hyperplasia.

Function:

1. Antioxidant;

2. Scavenging free radicals;

3. Lower cholesterol;

4. Boost immunity;

5. Prevent prostatic hypertrophy and prostatitis;

6. Good for man health.

Application:

1. Food additive;

2. Dietary supplement;

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Botanical and Herbal Ingredients

Premix Formula

Each uniform mixture is crafted from diverse ingredients, additives, and carriers, meticulously combined according to specific formulas to achieve targeted functions. The components of our premix products typically encompass a wide array of herb extracts, vitamins, minerals, and more. These premixes are part of our extensive product line, designed to cater to various needs and applications. By exploring our Products section, you can discover the full range of our premix offerings, each uniquely formulated to ensure optimal efficacy and quality, meeting the highest standards of our customers.

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Coix Seed Oil Product Name: Coix Seed Oil Botanical Source: Coix Lacrymajobi Appearance: Light yellow clear oily liquid Plant Part Used: Seed

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KINGHERBS LIMITED video introduction

Your Trusted Partner in Botanical Ingredients - Kingherbs

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Nutrition Premix-KINGHERBS

What is Nutrition Premix? A uniform mixture, made from different kinds of ingredients, additives and carriers according to a certain formula, referred to as "premix" or "compound premix". The ingredients, additives normally refer to all kinds of herb extracts, vitamins, minerals, etc.

Nutrition Premix can be classified according to different components:

1, Vitamins & Minerals Nutrition Premix

2, Plant Extract Nutrition Premix

3, Plant Extract & Vitamins, Minerals Nutrition Premix

According to different function, Nutrition Premix can be divided into below:

1, For Pregnant;

2, For Men's Energy;

3, For Children's immunity enhancing;

4, For Eye's Health;

5, For Sleeping Aid;

6, For Hair/Fingernail health;

7, For Pet's health/gross growth; 8, For Move Free; 9, For Liver Protection; 10, For Beauty; 11, For Joints Health; 12, For Anti-Nausea Support; 13, For Postpartum Formulation; 14, For slimming function; 15, For Calcium Magnesium Blend; 16, For Recovery Drink; 17, For VC protection; 18, For Collagen Plus; 19, For Energy Spray; 20, For Prebiotic & Digestive Enzyme; 21, For bird's health; 22, For male vasculas health;

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KINGHERBS LIMITED FACTORY INTRODUCTION

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KINGHERBS LIMITED FACTORY

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β-glucan enhances the body's immunity

Experts point out that attention in nutrition circles is focused on omega-3, probiotics and protein. But in the next few years, beta-glucan will be even more popular than omega-3, because of its role in boosting immunity.

At present, the beta-glucan market is pouring money into sports research. The Texas Marathon study showed that marathon participants who used beta-glucan had a 40 percent reduction in the incidence of upper respiratory illness, commonly known as colds, compared to a control group.

Following β-glucan binding, cells respond by producing various molecules that subsequently stimulate other cell types. This is why beta-glucan has such a broad range of effects, as it affects numerous cell types involved in immune and other responses.

For a long time, it was thought that beta-glucan only affects the immune response of cell types. However, later research clearly showed that beta-glucan also stimulates antibody responses, implying that it also has a direct effect on the humoral branch of the immune response.

Meanwhile, beta-glucan is also linked to the booming market for prebiotics and dietary fiber. β-glucan combined with vitamin C can enhance the microbiome in the gastrointestinal tract, and its effect on the body's immune function is currently being studied. The beta-glucan space will continue to grow as the nutrition industry takes notice of this niche market.

article from:Oat β-glucan---The "Dark Horse" among Natural Healthy Raw Materials - Kingherbs Limited