#bace1

[medicomunicare]

Le ultime sorprese del beta-amilode sul "da dove viene" e "che cosa realmente fa"

Nuove scoperte della Emory University stanno mettendo in discussione le teorie esistenti sulle origini dell’Alzheimer, una delle principali cause di demenza negli anziani in tutto il mondo. Un team di ricerca del Goizueta Brain Health Institute ha trovato solide prove a sostegno di una nuova comprensione dei meccanismi alla base della malattia di Alzheimer. I dottori Todd Golde e Yona Levites…

Le ultime sorprese del beta-amilode sul "da dove viene" e "che cosa realmente fa"

[neurosciencenews]

Researchers Successfully Reverse Alzheimer's Disease: Mouse Study

A team of researchers from the Cleveland Clinic Lerner Research Institute have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease, thereby improving the animals' cognitive function.

The research is in Journal of Experimental Medicine. (full open access)

[health-awareness-reviews]

Alzheimer's-disease-related proteases, BACE1 and APH1B-y-secretase, control ...

BACE1 is the major drug target for Alzheimer's disease, but we know surprisingly little about its normal function in the CNS. Soraia Barão and Bart De Strooper (VIB/KU Leuven) now show that this protease is critically involved in axonal guidance ... Read more at http://alzheimer.healthcrisis.info/?p=4580

[healthinnovations]

Researchers reduce Alzheimer's plaques by targeting glycosylation.

Researchers reduce Alzheimer's plaques by targeting glycosylation. Thoughts health innovators?

Researchers at the RIKEN-Max Planck Joint Research Center have demonstrated that hallmark symptoms of Alzheimer’s disease can be reduced when sugars are prevented from binding to one of the key enzymes implicated in the disease. The new findings show that abnormal attachment of a particular sugar to the enzyme BACE1 is a critical factor leading to the formation of Aβ plaques in the brain, and…

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