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SciTech Chronicles. . . . . . . . .November 25th, 2025
Vol IV Issue 33 Who Said that? One of the great tragedies of mankind is that morality has been hijacked by religion. Today, 308 links Curate
Study reveals new therapeutic option for head and neck carcinomas -- ScienceDaily
Study reveals new therapeutic option for head and neck carcinomas — ScienceDaily
The various manifestations of head and neck carcinomas rank sixth in frequency worldwide and are fatal for about half a million people every year. In a quarter of cases, head and neck squamous cell carcinoma (HNSCC) is caused by human papillomavirus (HPV) and, currently, is not always treatable. A research team led by Lorenz Kadletz-Wanke from MedUni Vienna’s Department of Otorhinolaryngology and…
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Non-DNA changes induce metabolism variations in hepatocellular carcinomas
Non-DNA changes induce metabolism variations in hepatocellular carcinomas
Cancer cells acquire growth advantages over normal cells in myriad ways. Changes in cell programming allow these cells to grow in an uncontrolled fashion, thereby forming the cancer mass. Hepatocellular carcinoma (HCC), being highly malignant and invasive with a high recurrence rate and drug resistant phenotype, is one of the most dreadful cancers. Understanding the underlying molecular…
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A Critical Study of Late Presenting Urachal Remnant Tumour: Rare Adenocarcinoma Originated from Developmental Defect | Chapter 10 | Trends in Pharmaceutical Research and Development Vol. 1
Occupying only 0.01% of all adult cancer patients, the rare entity urachal adenocarcinoma constitutes 22-35% of adenocarcinomas originating from urinary bladder. Though with the gradual descend of the bladder in the course of development urachus should turn into median umbilical ligament, exceptional persistence of it can give rise to urachal cyst or urachal adenocarcinoma in adulthood. With only 43% of survival rate for 5 years and mean survival between 12 and 24 months urachal carcinoma is a devastating disease. Diagnosis of it is based on the MD Anderson Cancer Centre (MDACC) criteria. Computed Tomography (CT) Scan and/or Magnetic Resonance Imaging (MRI) Scan of abdomen and pelvis are the major imaging modalities to proceed towards diagnosis and staging. Not only histopathological examination but also immune-histochemical expression of both CK7 and CK20 suffice to clinch the diagnosis. Though surgical intervention forms the mainstay of treatment, several regimens of chemotherapy have also been tried to fight against unresectable, residual, extensive urachal carcinomas. This case took place in a 52 years old male patient who was presented with a gradually enhancing infra-umbilical swelling with slow growing urinary symptoms. By dint of Ultrasonography (USG) and Contrast Enhanced CT (CECT) scan of whole abdomen the tumour was detected involving the bladder wall and the anterior abdominal wall. Cystoscopy was followed by upfront cytoreductive surgery. Histopathological examination revealed the diagnosis of an adenocarcinoma which was further confirmed to be an urachal remnant carcinoma with the help of immunohistochemistry. Postoperative CT scan showed residual disease involving bladder wall and was treated with an adjuvant platin based chemotherapy regimen.
Author (s) Details
Ipsita Dey
Department of Pathology, R. G. Kar Medical College and Hospital, Kolkata, India.
Tushar Kanti Das
Department of Pathology, R. G. Kar Medical College and Hospital, Kolkata, India.
Chhaya Roy
Department of Radiation Oncology, R. G. Kar Medical College and Hospital, Kolkata, India.
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http://bp.bookpi.org/index.php/bpi/catalog/book/156
Does Age Affect the Outcomes of Translocation Renal Cell Carcinoma? A Retrospective Analysis from A Middle Eastern Cohort
The natural history of Translocation renal cell carcinomas (tRCC) is variable from indolent behaviors to aggressive disease that demonstrates lymph node and widespread metastasis. Translocation renal cell carcinomas (TRCC) represent 1% to 5% of all cases of renal cell carcinoma (RCC). We sought to characterize the associations between age at presentation of tRCC patients and stage, grade, survival and recurrence of the disease in Middle Eastern institution. Materials and methods: Retrospective review of clinical and pathological data from a single institution for 23 patients diagnosed with tRCC between 2005 and 2017. Patients were categorized into two group based on age group 1 (>40 years) and group 2 (≤ 40 years). We evaluated the association between tumor grade, gender, disease free survival (DFS), overall survival (OS) and age. The tumor was on the right kidney in 52.2% of the patients, and bilateral in one patient. Ten patients (43.5%) were above 40 years of age, and 13 patients (56.5%) were less than or equal to 40 years old regarding the tumor characteristics, the mean tumor size was 9 cm; 4 patients (17.3%) had pathologic T1, seven patients (30.4%) had pathologic T2, 10 patients (43.4%) had pathologic T3 or more and two patients (8.7%) had no surgery. Eleven patients (47.8%) had lymph node dissection for clinically enlarged lymph nodes and seven (64%) of them had lymph nodes metastasis. Nineteen patients (83%) underwent radical nephrectomy and two (8%) had partial nephrectomy. Bilateral renal tumors were managed with left radical and right partial nephrectomy. There were no differences in DFS in patients above and below 40 years of age. No statistically significant associations between Disease-Free survival, gender, pathologic T staging, overall survival and age.
