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unless they turn out to be toxic or something i think the CGRP inhibitors and CGRP-focused treatment are going to be a BIG deal this decade. they aren't just acting on migraine pain receptors, they're broad-spectrum, and i found another study showing that adding CGRP to the eye with drops does something unexpected to treat dry eye disease. wonder how the additional CGRP in the patient ends up affecting them broadly
There's a new Migraine World Summit due in March, and they send out emails from the prior summit in the lead up.
One of the interviews last year was about the biology of migraine, and apart from being really interesting, it also highlights that migraine isn't a headache.
They think that one of the things to happen for a migraine attack to occur is for the trigeminal nerve to be activated/turned on.
There's a correlation between cortical spreading depression (when we have normal activity in the brain, and then there’s a depressed period where no activity can occur) and migraine with aura (eg, activity is the visual aura, and the cortical spreading depression is the period of darkness after), and that it may play a part in 'general' migraine.
A wave of electrical activity opens up the blood vessels and the covering around the brain, which allows for abnormal proteins like CGRP to be released.
CGRP and other proteins go and turn on the trigeminal nerve and other parts of the brain.
The trigeminal nerve - a large nerve that controls all facial sensation, in the head and the mouth - then turns on different parts of the migraine pathway, which includes activating various parts of the brain that correspond to migraine symptoms.
For example, this process disrupts the back part of the brain that controls vision, which is why you might become light sensitive during a migraine attack.
It can also affect parts of your brain that control appetite and your body temperature, which explains the stomach upset, nausea and difficulty regulating temperature when you have an attack.
All of this is happening because this nerve, the trigeminal nerve, is turned on and then goes and activates all these other parts of the brain.
Stupid nerve.
Fascinating, I wonder if anything's changed since last year in terms of research and how much more we know. We used to think migraine was caused by problems with the vascular system, and now we're really drilling down into the chemical and neurological activity that causes migraines
Having migraines is terrible, but if you're going to have them, now is a much better time than even 3 years ago.
Painting atop Emgality administration instructions.
I had my 4th Ajovy injection on Friday. My migraine frequency changed from daily to every other day about 2 weeks ago. I have a headache and some sudden nerve pain zaps on migraine-free days still but I’m hoping it’ll start getting better once I have less migraines. Current side effects: worsened asthma and sinusitis for a week following the injection, pretty bad constipation and really awful fatigue. But it’s better than having daily nonstop migraines.
I use cute plasters on the injection site and reward myself with candy, like a chocolate ladybug
(Previous post)
Thire grabs the bottle of moonshine and takes a swig, “We have to drink every time we knock the other down or the other falls.”
It‘s not going to be often in the beginning but the more they drink…
He grins and hands the bottle to Marlo before leading the way to the training rooms.
"You're on." Marlo says with a grin when he walks with Thire out of his office. When they reach the training grounds, Thire puts the bottle of moonshine down. Marlo strips himself of his armor until only his blacks are left.
"Wireeee", Lullaby gets up from his chair as soon as Wire enters thwir shared office. He looks more than miserable, his eyes a little bloodshot and his posture a little hunched over.
Nothing new. This always happens when Cody leaves for another unknown amount of time, perhaps not returning at all. It's just that one day of absolute hell for Lullaby, his emotional down after the euphoeric high of seeing Cody for a couple of days.
"Hey, Lullaby. You okay?" He asks worried as he sees how his fellow captain looks. He's not too surprised by this though. Lullaby usually has a period where he feels a bit more down after Cody has just left.
A new drug to treat migraines has been approved by the National Institute for Health and Care Excellence (NICE) for use within the National Health Service (NHS) territories of England and Wales. According to the Migraine Trust, more than 190,000 people suffer from migraine attacks every day in the UK,...
The U.S. Food and Drug Administration approved Eli Lilly's Reyvow (lasmiditan) for the acute treatment of migraines.
More promising developments in the management and prevention of migraines.
I personally tried Ajovy and it didn't do too much for me and now I'm taking Emgality. The jury is still out on that verdict...need a few more months to go by before any conclusions can be made.
I'm just excited that people are actively trying to find medical treatments for this disease. Keep 'em coming!
