#colchicine

[reserwrekt]

Dr: this medication is toxic, but you need to take it to live.

Dr: you might find you get super dizzy, sick, throw up, ect but eventually you'll start to feel better.

Dr: well hopefully.

Dr: I'll see ya in 3 months c:

[saralj-blog]

My evening thus far; studying for my two final exams next Monday.

Toxic Plants; Colchicine.

Jan. 4th, 2020.

[itsdoctorhouse]

Occam’s Razor

CC: Patient presents with cough, rash, dyspnea, syncope, and abdominal pain.

Dx: Colchicine poisoning

Syncope

Temporary loss of consciousness caused by a fall in blood pressure.

aka fainting, passing out

Hypothyroidism

Reduction in the production of the two hormones produced by the thyroid, T3 (triiodothyronine) and T4 (thyroxine). 

The two hormones regulate the body’s temperature, metabolism, and heart rate. 

T3 is the active hormone, T4 is the precursor, both circulate through the bloodstream.

T3 functions include the 6 B’s:

Brain maturation

Bone growth

Beta-adrenergic effects

Basal metabolic rate

Blood sugar (glycogenolysis, gluconeogenesis)

Break down lipids (lipolysis)

Most commonly affects women above the age of 50.

Symptoms include:

Goiter: enlargement of the thyroid gland, it’s the characteristic neck mass shown in most tv shows, not to be confused with enlargement of salivary glands which show growth more along the jawline.

Metabolic: Cold intolerance, hypohidrosis (reduction in sweat production), weight gain, hyponatremia (reduced sodium in the bloodstream)

Skin/hair: Dry, cool skin (due to reduced blood flow), coarse, brittle hair, diffuse alopecia, brittle nails, puffy facies and generalized nonpitting edema (aka myxedema)

Ocular: Periorbital edema

Gastrointestinal: Constipation, reduced appetite

Musculoskeletal: Hypothyroid myopathy (proximal weakness), carpal tunnel syndrome

Reproductive: Abnormal uterine bleeding, reduced libido, infertility

Neuropsychiatric: Hypoactivity, lethargy, fatigue, weakness, central nervous system (CNS) depression, reduced reflexes

Cardiovascular: Bradycardia, dyspnea on exertion

Common underlying causes:

Iodine deficiency - because the hormones are basically composed of iodine with some extra spice.

Malfunctioning pituitary gland - because the pituitary gland signals the thyroid to produce hormones (through TSH-Thyroid stimulating hormone), classified as Secondary Hypothyroidism because the problem does not directly derive from the thyroid.

Trauma to the thyroid gland.

There are a lot of other etiologies/causes that I can’t go over one by one just by necessity because the list would add another 10 pages. But my favorite is definitely cretinism (congenital hypothyroidism) just because it was actually mentioned in Paternity (s01e02) as part of a crossword puzzle.

Colchicine poisoning

Pharmacy error in this case, a switch-up with the cough medicine.

Used to treat gout: a form of inflammatory arthritis, characterized by recurrent attacks of red, tender, hot and swollen joints. Due to persistently elevated levels of uric acid in the blood which form crystals within joints and kidneys.

Overdose begins with a gastrointestinal phase 10-24 hours after ingestion, followed by multiple organ dysfunction 24 hours to 7 days after ingestion.

Symptoms include: 

Burning in the mouth and throat, fever, vomiting, and abdominal pain.

Hypovolemic shock due to extreme blood/fluid loss through the gastrointestinal tract.

Kidney failure follows 

Alopecia: loss of hair, aka baldness

Bone marrow depression: decrease in production of cells responsible for providing immunity, carrying oxygen, and/or those responsible for normal blood clotting. 

Agranulocytosis: lowered white blood cell count

Aplastic anemia: failure of production of blood cells

[teufelskunst]

The #meadowsaffron, or #autumncrocus, as it is also called, is a highly fascinating plant. Its purple flowers look like crocuses, but appear in early autumn, when most other plants are done flowering. This is also reflected in its German name #herbstzeitlose, which means “autumn messenger”. From the “naked” flowers may also be derived the English moniker “naked ladies”. The leaves, on the other hand, show up in spring and have been mistaken for bear’s garlic. A dangerous and potentially deadly mistake, since the entire plant contains the alkaloid #colchicine, which acts similar to #arsenic, and has no known antidote. In addition it has a long latency period, which makes poisoning with autumn crocus even more difficult to recognize and treat. While deadly, it is also made use of in medicine, for treating certain types of cancer, as well as in plant breeding, where it causes plants to grow larger and produce bigger fruits. A plant named #colchicon was first mentioned by #dioscorides. The specific name autumnale given by Linnaeus, refers to its time of flowering. The genus name Colchicum is derived from #colchis, the landscape on the Black Sea, most famously known for the witch #medea, who is told to have poisoned her enemies with meadow saffron, but also restored youth with its help. In Apollonius Rhodius’ Argonautica, Medea rubs a salve on Jason’s limbs, which contains meadow saffron. According to another legend, meadow saffron grew from the blood that dripped from #prometheus’ liver. However, the same story is also related to the Mandrake and both plants are candidates for the mythical plant named “blood of Prometheus”. The #artwork shown here is one of my more #illustrative works, combining #symbolism and showing the #plantspirit in an #anthropomorphic form. It was first show-cased in 2017 at gallery Circle1 in Berlin, as part of the “Bad Intentions” group exhibition. It is drawn with black #ink on paper that has been stained with coffee and meadow saffron flower extract. It is signed on the back and comes in a simple black cardboard passe-partout. #originalart #inkdrawing #sigillamagica #occultart #witchplants #poisonousplants #colchicumautumnale https://www.instagram.com/p/BrDcyOcniwg/?utm_source=ig_tumblr_share&igshid=jh4zy29oy070

[er-cryptid]

Colchicine

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[clinicalherbalist]

Colchicum autumnale, nicknamed fall crocus, seeming to glow from within as it is illuminated by the low-angled light of a fall afternoon at the 45th paralell. The underground bit of this plant contains an alkaloid called colchicine, which strongly stimulates the kidneys. It is used as a drug for gout (never use it, there are better ways to treat gout) and also for familial mediterranean fever, for which it makes an enormous clinical difference and is entirely appropriate. It's named after Colchis, the kingdom from the story of Jason and the Argonauts, which was where Georgia and Abkhazia are now . . . . #colchicum #colchicine #crocus #butnotreally #flowers #herbalmedicine #pharmacognosy #alkaloid

[sarvbiolab]

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[sarvbiolab]

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