#cyclopia

[duel-styx]

Sin snake stickers, inspired by Cult of the Lamb and based on the mud snake (Farancia abacura). Cyclops as they be, so a little bit of teratology too.

[princessofghosts-posts]

Hold up,I just found out that there is a condition where a human can be born with only one eye,and it's a birth disorder called cyclopia. Like the cyclopes in mythology.

Now,what if the mist fails and the mortals see some bits of cyclopes,but they are like "Omg,poor soul,they have cyclopia. I hope life will be kind to them." And the poor cyclop is just there like "??? Tf you talking about?? I'm good?"

[boonoftheforest]

ANOTHER redesign, brooke!

[kekekechuchu]

_Red Sovereign_

"Despite all the warmth emanating from spoken words, their hands were still cold to the touch."

[ppaleoartistgallery]

Paleostream 8/07/2023

results of today's paleostream!

today we drew Cacops, Pliosaurus, Pampaphoneus, and Ufudocylops (mine is a juvenile with cyclopia)

[justkidneying]

An Example of Scientists Being Nerds

What do Sonic the Hedgehog and cyclopia have to do with each other? A lot, actually.

Alobar holoprosencephaly (aka cyclopia) is a condition in which the prosencephalon does not properly split during development. Let me explain what that means. So, one of the most important structures in the early embryo is the neural tube. This tube comes from the ectoderm and eventually becomes the central nervous system. The top of it has three little bulbs and the bottom is the spinal cord.

The top bulb is the prosencephalon, which will later differentiate into the telencephalon and diencephalon. These will become the cerebral hemispheres, basal ganglia, thalamus, hypothalamus, and amygdala. The middle bulb is the mesencephalon, which will become the midbrain. The bottom bulb is the rhombencephalon, which will differentiate into the metencephalon and myelencephalon. These will become the pons, cerebellum, and medulla.

So, this entire thing has to split in half anteriorly. The anterior portion of this structure deals with motor function, and the posterior half deals with sensory function. This holds true as an adult. The front half of your spinal cord carries motor nerves, and the back half carries sensory info. If you want to move your eyes, you use the front part of your brain. If you want to know what you are seeing, you use the back half.

If you look at your spinal cord, the front half has this fissure down the middle (anterior median fissure is such a fitting name, then right??). Your brain is also split down the middle. Since the eyes are part of your brain, you get one for each half of the brain (two). Now, let's say you never have this anterior fissure form... you won't get two eyes, either. The condition where the fissure doesn't form is called holoprosencephaly (holo means whole).

There are five types of this (in order of decreasing severity): alobar, semilobar, lobar, syntelencephaly, and microform.

*note that the more severe the condition is, the more likely the fetus will die and not form all structures mentioned*

Alobar: there will be one eye, a proboscis (fleshy tube on the face), and severe mental impairment.

Semilobar: eyes will be close together, the nasal bridge will be flat, the palate and lip will be cleft, and there will be mental and ocular impairment.

Lobar: the eyes will be close together, the nasal bridge will be flat, the nostrils will be close together, and there will be some mental impairments.

Syntelencephaly: flat nasal bridge, shallow philtrum, and possible mental delays.

Microform: eyes may be close, nasal bridge will be sharp, and there will be one central upper incisor.

Okay, so what does this have to do with Sonic the Hedgehog? Sonic hedgehog (SHH) genes, of course! This gene codes for the sonic hedgehog protein, which controls what happens during organogenesis (how everything differentiates and forms). A mutation in this gene can cause issues with how embryos form, and is indicated specifically in holoprosencephaly. SHH genes are still important in adults, and mutations can be linked to certain cancers.

Fun fact: an inhibitor of SHH genes is called Robotnikinin. I personally love this. And, here's a citation in case you don't believe me: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770933/

[octahedral-chaos]

Okay second Ratatan/ Genshin oc down!

Her name is Workneh, they're a oddball Pari (that also has Cyclopia bizarrely enough) that has somehow got transported to Redo in her youth, was raised by a group of outlaws from the Yeehawler Mountains and now scouts the land... in order to protect it!

They use her trusty Stroh's Violin to blast soundwaves to keep enemies at bay... and their special also deals a great amount of knockback AND damage! But there's a catch: your OWN allies may unintentionally get caught in the blast, but do not fear! The blast only throws them into the other direction, not harm them! You should still wear ear protection, thought...

She's based off of the song "Rountable Rival" by Lindsey Stirling, as well as Western Aesthetics in general.

Image ID under cut!

[Image ID: A digital drawing of a Pari (Genshin Impact). They seems to have cyclopia (One large fused eye at the center of her head), and is mainly Pancho in colour, with five scarlet petals on their head, pointing backwards. Her single eye has scarlet sclera and Bright Sun iris/ pupil. Their tail has a Burnt Sienna gradient near the tip, as well as a scarlet tip/ "bud", and also scarlet wing tips. She is wearing headphones with Prussian blue earcups/ earpads and Anakiwa blue band, a poncho that is mainly Fire brown with Scarlet lining on the lower area and Anakiwa blue on the upper side, and a Fire brown "belt" with two Anakiwa blue diamond-shaped jewels attached to it by black threads. They are holding a Stroh's Violin and bow, the violin mainly being Cedar Wood Finish, with black strings and pegs, Bright Sun Bridge and horn, and a Prussian blue lining around the horn's Bell. The bow is mainly Fire brown with Anakiwa blue strings. She is looking to the right, while also playing the violin. /End ID]

[obscurecore]