Apr 19
This study assessed the diuretic potential of methanolic extract of Hydrocotyle vulgaris in albino mice after oral administration. Methanolic extract of H. vulgaris (40 and 20mg/kg) and the reference drug, Furosemide (20mg/kg) were administered intraperitoneally using the modified Lipschitz method. All animals were pretreated with saline before commencing the experiment. Their urine output and electrolyte changes were quantitated at several intervals of time after the dose of 5 hours and after 24 hours. The urine output increased significantly in Furosemide and in both 40 and 20mg/kg extracts (p