NET- new theory to fight devils
Formation of extracellular traps are really smart move by innate immunity when body encounters potential threats.These structure consists of a chromatin-DNA backbone with attached antimicrobial peptides and enzymes that trap those microscopic devils and kill them with process different from phagocytosis and necrosis.when body encounter these threats, stimulation of neutrophils and mast cell by phorbol ester, , chemoattractant peptides, or chemokines, the generation of reactive oxygen species (ROS), such as hydrogen peroxide, by NAPDH oxidase initiates a signaling cascade that leads to the disintegration of the nuclear and cellular membranes and the formation of ETs.It is neither phagocytosis nor necrosis rather occurs because of oxidation of phosphatases or kinases.side effet of this formation is autoimmuno disease like rheumatoid arthritis and glomerular nephritis.