#estrogen

[status-quo-hater]

Honestly I don't think you should need a diagnosis of anything to get HRT. I think you should just be able to go buy it at CVS like it's ibuprofen.

[coyoteguuurl]

i dont know who needs to hear this, but 2mg is not enough. frankly 8mg is not enough. buy your estrogen elsewhere. take anywhere from 50-100% more than the WPATH recommended max dose. stop once your estrogen stays around 300-450 pg/mL. try not to exceed 700 pp/mL (excess estrogen causes the body to purge estrogen, often overreacting and putting your total effective estrogen lower than what is desirable for feminization and stability).

there is no conclusive evidence that the feminizing effects of injectable E are preferable to those of oral E, but injectable is safer long-term (years-long), so eventually switch to injectable. its cheaper also.

use a good anti-androgen. spiro will make you piss and pissed, because it sucks. take bica 50mg or cypro 12.5mg. misc notes on anti-androgens:

if you've already been on E for over a year and your E is above 250pg/mL and your T is below 50ng/dL, you won't really benefit from an anti-androgen. If you're earlier in your transition than that, or if your levels aren't looking like that, you can either increase your estrogen intake (try not too exceed a blood estrogen level of 700pg/mL, or take an anti-androgen. there is no conclusive clinical evidence to say that monotherapy is better or worse than E + AA, it's kinda just personal preference.

there are two things to be wary of with bicalutamide; first, it's hell for your liver. if you like to drink, don't take it. if you take it, get liver enzymes taken when you get blood labs pulled. second, bica does not stop T production, only reception, so it should only really be taken if you plan on getting an orchiectomy (thus removing the testes). If you plan on keeping your testes, use cypro.

if you take cypro, get a vitamin b12 (or general b) supplement. cypro eats away at b12 reserves which can sometimes cause depression and other mental health symptoms.

take your prog. take 200mg. if youre putting it in your mouth, take more until youre emotional but stable. if youre putting it in your butt - PUTT IT IN YOUR BUTT - take more, but less than you would if it were in your mouth.

work out. work your ass, your thighs, your abs. get sweaty. the more growth hormones you can get through your body, the more effectively your estrogen will feminize you (this includes your tits).

eat more. eat at least 25% more than your maintenance. eat lots of protein, but also lots of fat. your ass and tits will thank you very jiggly.

and most importantly; show me. im a pervert.

[thankstothe]

big if true

[misspetbait]

being on estrogen is so fucked up. all i wanna do is show off my tits to everyone but apparently that's "weird" and "inappropriate"

[casual-haterism]

yeah you can get cancer-in-a-stick just about at every store and gas station when youre of age but hrt is scary and experimental and new and older than fucking microwaves you cant have that

[crossdreamers]

Groundbreaking study could revolutionise HRT for trans women

A study into the effects of different forms of HRT could change the way hormones are prescribed in the future.

Research supports a shift toward estradiol monotherapy for trans women, using estradiol alone without additional testosterone blockers.

A groundbreaking study published in the Journal of the Endocrine Society reveals that injectable estradiol may significantly improve hormone therapy outcomes for trans women, Pink News reports.

Researchers analyzed data from 29 patients who switched from traditional estradiol forms (gels or tablets) to weekly injections over a 15-month period. Despite receiving a lower average dose (3.7 mg vs. 4.3 mg), all participants experienced a dramatic reduction in testosterone levels, while maintaining stable estrogen levels.

The study also challenges the efficacy of Spironolactone, a commonly prescribed anti-androgen.

From the research paper Injectable Estradiol Dosing Regimens in Transgender and Nonbinary Adults Listed as Male at Birth: Results The average estradiol dose decreased from 4.3 to 3.7 mg weekly (P < .001) during the study period with a final on-treatment estradiol level of 248 pg/mL. All individuals achieved a testosterone level of less than 50 ng/dL during the study period. The average initial on-treatment testosterone level was not significantly different from average final on-treatment measurement of 24.0 mg/dL (P = .95). Spironolactone use at study initiation was not associated with a lower initial on-treatment testosterone level, though it was associated with a lower estradiol level of 285 pg/dL compared to 427 pg/dL for those on estradiol monotherapy (P = .017). Conclusion Lower doses of injectable estradiol can achieve therapeutic estradiol levels with excellent testosterone suppression. Spironolactone was not associated with additional testosterone suppression and may result in lower estradiol levels.

Photo: Getty

[lemmaeof]

huge news for trans women - estrogen does not lead to an increased cardiovascular risk!

Transgender persons receiving gender-affirming hormone therapy: risk of acute cardiovascular events in a Dutch cohort study

AbstractBackground and Aims. Despite favourable effects of oestradiol on cardiovascular risk factors, previous studies found higher risks of

This retrospective cohort study included transgender women and transgender men using gender-affirming hormone therapy between 1972 and 2018 at the Amsterdam gender clinic. Medical diagnoses were registered from 2012 to 2022 by a national data registry. Standardized incidence ratios for myocardial infarction, ischaemic cerebrovascular accident, and venous thromboembolism were computed using general population incidence rates adjusted for socioeconomic status, estimated by education, employment, and income. Lifestyle (body mass index, smoking, and alcohol consumption) was analysed by age group.

Gender-affirming hormone therapy is not associated with increased cardiovascular risk in transgender women but is in transgender men. This aligns with known effects of oestradiol and testosterone on cardiovascular risk factors.