Order Abatacept (Orencia) in India – Price & Import Support
What is Abatacept?
Abatacept is a soluble fusion protein produced by recombinant DNA technology, with the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) linked to the modified Fc portion of human immunoglobulin G1. Patients looking to buy Abatacept in India usually access it through regulated import programs.
It inhibits T cell activation by binding to CD80 and CD86, and thus blocking interaction with CD28. This interaction provides a costimulatory signal necessary for full T cell activation. Activated T lymphocytes are implicated in the pathogenesis of rheumatoid arthritis and are found in the synovium of patients with RA.
Who is it for?
Abatacept is indicated fpr reducing signs and symptoms
By inhibiting progression of structural damage and improving physical function in adult patients with moderately to severely active rheumatoid arthritis. Abatacept can be used as a monotherapy or concomitantly with disease modifying antirheumatic drugs besides TNG antagonists or other biologic rheumatoid arthritis therapy such as Anakinra.
In pediatric patinets 6 years and older with moderately to severely active polyarticular juvenile idiopathic arthritis, as a monotherpay or concomitantly with methotrexate.
How is it given?
For adult patients with rheumatoid arhthritis, abatacept may be administered as an intravenous infusion or a subcutaneous injection. Abatacept intravenous should be administered as a 30-minute intravenous infusion utilizing the weight range-based dosing in as specified in the FDA label. Following initial intravenous administration, an intravenous infusion should be given at 2 and 4 weeks after the first infusion and every 4 weeks thereafter.
Abatacept 125 mg should be administered by subcutaneous injection once weekly and may be initiated with or without an intravenous loading dose.
The recommended dose of abatacept for patients 6 to 17 years of age with juvenile idiopathic arthritis who weigh less than 75 kg is 10 mg/kg intravenously calculated based on the patient’s body weight at each administration. These formulations are commonly supplied when patients import Abatacept through approved channels.
Benefits of Abatacept
Abatacept aids in reducing rate of joint damage, inflammation and pain associated with rheumatoid arthritis
It can improve mobility and flexibility in arthritis patients
It is suitable for patients not responding to disease-modifying antirheumatic drugs
Safety and side effects
Serious infections like sepsis and pneumonia have been reported in patients receiving abatacept. Prior to initiating treatment patients must be screened for latent tuberculosis test and viral hepatitis in accordance with published guidelines before starting abatacept therapy. Live vaccines should noyt be given concurrently with abatacept within 3 months of its discontinuation. Based on its mechanism of action, abatacept may reduce the effectiveness of immunization in some cases. Adult patients of chronic obstructive pulmonary diseases who were treated with abatacept developed some adverse events that included exacerbation of COPD. Also, drugs inhibiting T cell actiivation like abatacept, affect host immune defense against infections and malignancies.
There are no adequate well-controlled studies of abatacept use in pregnant women. Animal studies show abatacept crossing placenta and presence in rat milk. Hence, abatacept should be used during pregnancy and in nursing mothers only if potential benefit to the mother justifies the potential risk to fetus or baby. Immune system abnormalities like increase in serious and lethal infections and thyroid or pancreas inflmmmation have also been reported in animal studies. Safety and effectiveness of abatacept in peditaric patients below 18 years of age has not been established. No overall differences in safety and effectiveness were observed in the very few patients who were studied and are above the age of 65 years.
Storage and handling
Abatacept or Orencia is available as lyophilised powder for intravenous infusion in strength of 250 mg single use vial and as solution for subcutaneous injections in strength of 125 mg single vial.
Abatacept lyophilized powder or prefilled syringe should be refrigerated at 2℃ to 8℃ (36℉ to 46℉ ). Do not use beyond the expiration date on the vial or prefilled syringe. Protect from light by storing in the original package until time of use.
Price and availability
Abatacept can only be made available if the patient provides a valid doctor’s prescription, as it is not accessible through channels such as general pharmacies or pharmaceutical distribution channels. in India. Patients often enquire about Orencia price in India, which varies depending on sourcing and import requirements.
We comply with all import regulations and cover services like document verification, import coordination, and doorstep delivery of the medicine to make these products available.
Prices for medicines and products are subject to variation due to market demand, supplier access, import formalities and local taxes. Final costs will include charges associated with shipping, origin country, documentation fees and exchange rates.
We can help safely and legally access Abatacept through the Named Patient Supply (NPS) program, adhering to applicable legal and regulatory standards.
For patients looking to buy Abatacept in India can receive a price quotation after medical document and prescription verification. Our team is open to any queries or details related to import of abatacept in India.
For updated pricing, availability, and supply support for abatacept in India, visit 247qualitymeds.com to connect with our dedicated support team.
Import procedure
Medicine Request Submission: Patients or caregivers must submit a request, along with their doctor’s prescription and treatment information to initiate the import process.
Filing Form 12A: Next, a completed Form 12A and a valid prescription from a Registered Medical Practitioner (RMP) must be submitted.
Verification Process: All documents are carefully reviewed to confirm the patient’s eligibility to import the medicine for personal medical use.
Regulatory Approval: Once approval is received from the Drugs Controller General (India), the import procedure is initiated in accordance with the approved prescription.
Medicine Procurement: Our procurement specialists will connect with licensed international suppliers to source the medicine to customers at the best possible rate while ensuring authenticity and quality.
Product Delivery: Following approval and shipment, logistics are handled to ensure timely, safe, and compliant delivery of the medicine to the patient’s address in India.
What are the documents required ?
To import abatacept to India, patients must provide the following:
A valid prescription indicating the medicine name, dosage, duration, and diagnosis.
Recent medical history and reports (preferably from the last three months) confirming diagnosis.
Government-issued ID proof and proof of residence.
Import permit (if required).
Note: The orders are confirmed and processed only after all required documents have been submitted and verified. Once the import permit is approved, abatacept is sourced through an authorized global distributor. This structured pathway ensures that patients in India receive the medicine legally and safely.
Our team works closely with accredited international suppliers, providing clear and honest pricing to our customers, and guarantees that every shipment is reviewed by qualified pharmacists and shipped in full compliance with regulatory standards. We make the medicine available across major cities, sourcing only from genuine international suppliers to ensure quality and authenticity. We maintain complete transparency in pricing, and all prescriptions are reviewed by registered pharmacists before final dispatch.
Read related article: Abatacept (Orencia) Injection in India: Price, Uses & Import Guide