The following is an idea, and not something I intend to write.
Premise: Spider-Man Hamlet AU. When Harry's father dies, he suspects foul play. His suspicions seem to be confirmed when his old friend, Peter Parker, comes out of nowhere to take control of his father's business.
The company/board of directors: Gertrude
Gwen: Ophelia/Guildenstern/Laertes
Norman dies in a fight with Spider-Man. In his will, he stated that his business should be left to Peter alone. Harry got the penthouse and stuff but he had been working towards taking over Oscorp his whole life so this hurts, and it's the first thing that leads him to become suspicious of Peter.
The fight was basically the fight from the Sam Raimi movies. Peter blames himself. Also, Harry was at college when the fight happened.
The board of directors decide to have Peter's first press conference and CEO/owner induction the day after the funeral. This looks bad to Harry.
Peter keeps trying to talk to Harry but things keep interrupting him and he is never able to tell Harry what's going on.
Harry feigns a deep depression with dissociative episodes (he read about it on the internet) in order to explain why he is in rooms that he shouldn't be in while he is searching for answers
He talks to MJ and Gwen about his discoveries, but discovers that they're also talking to Peter. He starts to push everyone away in his search for answers (and revenge!). He determines that Peter must have hired Spider-Man to kill his father in order to inherit the company. This is untrue.
He confronts Peter, and they fight, killing Police Captain Stacy in the process.
Gwen is not sure who to blame but she is seeking revenge now too.
There is no suicide. MJ gets fed up with the drama (it's hurting her career and people keep lying to her and it hurts to go behind her friends' backs) so she leaves to pursue her career.
Gwen blames Harry for MJ leaving because Harry is the main source of conflict.
Et cetera, we know about Hamlet. But wouldn't this be cool?