This study was conducted in Tumalutab Island, Zamboanga City. It aimed to establish the qualitative profile of medicinal plants used as ethnomedicinal practices of the Sama Bangingi group in Tumalutab Island, Zamboanga City. The collection of data was done from December 2021 to January 2022. Purposive sampling was utilized as sampling method. A survey was conducted to establish the quantitative profile, interview and semi-structured questionnaires were utilized. The collection and identification of plants were pressed and mounted using the herbarium techniques and the validation of identified plant species was verified after. Thirty (30) medicinal plants were cited by the respondents, eleven (11) families were identified. This indicates that leaves (60%) are the most part of the plant used for treatment, followed by roots (16%), bark (10%), whole plant (11%) and flower (3%). The top three mode of preparation being used by the Sama Bangingi tribe are decoction (73%), pounding (11%), and infusion (10%). The mode of administration is as follow; wherein drinking has (75%) marks the highest number of modes of preparation followed by applying the plant as poultice (21%), and applying it externally (4%). Researchers suggested that to explore the potential of medicinal plants used by the Sama Bangingi tribe by performing In vitro assays to assess the potential therapeutic effects of the components present in each medicinal plant.