Jul 4, 2022
While he said it is "too soon to tell" whether BA.2.75 will be the next dominant variant, he noted that the sub-variant might be "alarming b
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While he said it is "too soon to tell" whether BA.2.75 will be the next dominant variant, he noted that the sub-variant might be "alarming b
A study using Marek's disease virus in poultry shows that by reducing natural selection against highly virulent strains, imperfect vaccinati
Abstract
Could some vaccines drive the evolution of more virulent pathogens? Conventional wisdom is that natural selection will remove highly lethal pathogens if host death greatly reduces transmission. Vaccines that keep hosts alive but still allow transmission could thus allow very virulent strains to circulate in a population. Here we show experimentally that immunization of chickens against Marek's disease virus enhances the fitness of more virulent strains, making it possible for hyperpathogenic strains to transmit. Immunity elicited by direct vaccination or by maternal vaccination prolongs host survival but does not prevent infection, viral replication or transmission, thus extending the infectious periods of strains otherwise too lethal to persist. Our data show that anti-disease vaccines that do not prevent transmission can create conditions that promote the emergence of pathogen strains that cause more severe disease in unvaccinated hosts.
Author Summary
There is a theoretical expectation that some types of vaccines could prompt the evolution of more virulent (“hotter”) pathogens. This idea follows from the notion that natural selection removes pathogen strains that are so “hot” that they kill their hosts and, therefore, themselves. Vaccines that let the hosts survive but do not prevent the spread of the pathogen relax this selection, allowing the evolution of hotter pathogens to occur. This type of vaccine is often called a leaky vaccine. When vaccines prevent transmission, as is the case for nearly all vaccines used in humans, this type of evolution towards increased virulence is blocked. But when vaccines leak, allowing at least some pathogen transmission, they could create the ecological conditions that would allow hot strains to emerge and persist. This theory proved highly controversial when it was first proposed over a decade ago, but here we report experiments with Marek’s disease virus in poultry that show that modern commercial leaky vaccines can have precisely this effect: they allow the onward transmission of strains otherwise too lethal to persist. Thus, the use of leaky vaccines can facilitate the evolution of pathogen strains that put unvaccinated hosts at greater risk of severe disease. The future challenge is to identify whether there are other types of vaccines used in animals and humans that might also generate these evolutionary risks.
The Proliferation of COVID Variants
The vaccine can not prevent infection nor transmission. By again increasing the antibodies (with the booster), the virus is put under...
From an immunological point of view, boosters and mass vaccination are as harmful as mold on a wall, December 1, 2021
Q&A with Geert Vanden Bossche #1
Question: Should vaccinated people go get their booster shots or not?
Answer: From an immunological point of view, boosters and mass vaccination in general are as harmful as mold on a wall.
The vaccine can not prevent infection nor transmission. By again increasing the antibodies (with the booster), the virus is put under an even higher immune pressure while further expanding its capacity to escape from the vaccinal antibodies (Abs). As a result more infectious variants gain a competitive advantage and hence, will spread stronger amongst the population. This only precipiates and expands the evolutionary capacity of the virus to resist the vaccines. The level of protection WHO has recently been claiming (40%) is anything but due to the vaccines and can only be ascribed to some ‘trained’ innate immunity large parts of the population acquired prior to vaccination as a result of asymptomatic/ mild infection. It is crystal clear, indeed, that none of the C-19 vaccines is capable of blocking transmission, not even by 1 % ! Because vaccinal Abs suppress relevant innate Abs, these vaccines have no capacity whatsoever to confer sterilizing immunity. Consequently, none of these vaccines help to build herd immunity; on the contrary, they generate a breeding ground in vaccinees for more infectious variants, thereby further increasing infection rates and threatening both the unvaccinated and vaccinated. Moreover, vaccinal Abs tend to outcompete innate Abs for binding to SARS-CoV-2 because of their higher affinity for the virus. This particularly applies to naive innate Abs (children!) and already explains why C-19 vaccination is at risk of dramatically weakening people’s first line of immune defense, especially in children. Our innate immunity is not only well armed to protect against COVID-19 (including all its variants!), but also against a number of other viruses causing acute respiratory disease. There can be no doubt, therefore, that such an assault of our immune system will have dramatic consequences on both individual and public health. Basically, mass vaccination is now turning Covid-19 into a disease of young and healthy unvaccinated people while enabling the virus to break through both the innate and adaptive immune defense of vaccinees due to vaccine-mediated suppression of innate Abs and viral resistance to vaccinal Abs, respectively. For those who didn’t get it thus far, Omicron will repeat that lesson; its teaching will only be a bit tougher and will soon silence all those who are trying to convince their people that they can outsmart the virus and, as they ridiculously claim, ‘stay ahead of the virus’.
The media can read just as well as me (maybe), but somehow it is left to me to report this.
BOMBSHELL UK data destroys entire premise for vaccine push
by Chris Waldburger
The media can read just as well as me (maybe), but somehow it is left to me to report this
This is an absolute game-changer.
The UK government just reported the following data, tucked away in their report on variants of concern:
Less than a third of delta variant deaths are in the unvaccinated.
Let me say that another way - two-thirds of Delta deaths in the UK are in the jabbed.
To be specific:
From the 1st of February to the 2nd of August, the UK recorded 742 Delta deaths (yes, the dreaded Delta has not taken that much life).
Out of the 742 deaths, 402 were fully vaccinated. 79 had received one shot. Only 253 were unvaccinated.
The report is here.
But this is the crucial page. Look at the bottom line.
Again, 402 deaths out of 47 008 cases in vaccinated; 253 deaths out of 151 054 cases in unvaccinated. If you get covid having been vaccinated, according to this data, you are much more likely to die than if you were not vaccinated!
Obviously some allowance must be made for more elderly people being vaccinated, but not enough to change the bottom line: this vaccine is not nearly as effective as advertised.
And with all its unknowns, and a much higher adverse reporting number than all other vaccines combined, a complete recalibration of global policy is the only moral option.
Countries around the world, as months pass since vaccinations, are experiencing a surge in vaccinated deaths and hospitalizations. 60% of hospitalizations in Israel are fully vaccinated patients. (Hence the mad rush for untested boosters.)
The powers that be will not admit there is something terribly wrong. They will not acknowledge the clear science that people with natural immunity, and the young and healthy, do not need to take the risks of these injections. Read this very important piece on natural immunity. Reliable studies showing the superiority of natural immunity are just ignored by our overlords.
Instead they will jab and jab and jab again. The vaccine passports will be renewable every six months. Countries are ordering up to 8 shots per citizen. The masks will not go away. Israel, the pre-eminent vaxxed nation, is in lockdown.
The report also made one other important admission:
In other words, getting vaccinated to protect others is not true!
This is NOT a sterilising vaccine that stops diseases like polio or hepatitis using live virus. This is for you alone. Which means, as experts like Martin Kulldorff, biostatistician, epidemiologist and professor of medicine at Harvard Medical School, and Jay Bhattacharya, professor of medicine at Stanford University and research associate at the National Bureau of Economic Research, have long said, it makes zero sense to vaccinate the young and healthy.
We are dealing with a world-historical error, and in fact a global assault on young bodies.
To be clear, I make no advice to anybody about taking the vaccine or not. I may well have decided to take it if I were in a risk category, or if I knew I did not have to wear a mask or get tested after taking a single shot. Your decision should be guided by consulting with a doctor, informed consent, and your own conscience.
And you should ask yourself why there is no explanation for the hundreds of thousands of women experiencing menstrual changes after the shot, or the way vaccines are being mandated at the same time they are under investigation for unknown risks.
What I will say categorically is that you will have to answer one day, in this life or the next, for where you stood on the issue of mandating medicine for the healthy without informed consent, on giving cover for governments to shove things down kids’ noses, and locking down all that makes life worthwhile. Where were you when kids’ freedoms were stolen from them? I doubt there will be much forgiveness from that generation.
Every time somebody posts a meme mocking vaccine hesitance, not only do they alienate the hesitant, and radicalize them, they implicitly endorse a new police state in which a liberal government like Australia feels empowered to pepper spray kids in the face for not wearing a mask that has not been conclusively shown to prevent viral transmission.
For crying out loud, this what even the World Health Organization admits about masks:
The vaccines will not end these measures, especially in countries with low vaccination rates. They cannot, unless these governments admit their massive errors. Their booster shot push makes this unlikely.
Finally, why does the media not even report on governmental data? Why am I reporting this stuff?
I have no idea, but it is truly sinister.
Ask yourself why the media will not even mention the fact that this 23-year-old Irish footballer below, in perfect health, received a vaccine three days before dropping dead:
Untimely indeed.
God have mercy.
Officials are trying to understand why some of LA's highest coronavirus case rates are currently in communities with high vaccination rates.
Note that views expressed in this opinion article are the writer’s personal views and not necessarily those of TrialSite. Summary As Sars-CoV-2 entered a
Highlights
Infection-enhancing antibodies have been detected in symptomatic Covid-19
Antibody dependent enhancement (ADE) is a potential concern for vaccines
Enhancing antibodies recognize both the Wuhan strain and Delta variants
ADE of Delta variants is a potential risk for current vaccines
Vaccine formulations lacking ADE epitope are suggested
Abstract
Antibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies. In a recent publication, Li et al. (Cell 184 :1-17, 2021) have reported that infection-enhancing antibodies directed against the N-terminal domain (NTD) of the SARS-CoV-2 spike protein facilitate virus infection in vitro, but not in vivo. However, this study was performed with the original Wuhan/D614G strain. Since the Covid-19 pandemic is now dominated with Delta variants, we analyzed the interaction of facilitating antibodies with the NTD of these variants. Using molecular modelling approaches, we show that enhancing antibodies have a higher affinity for Delta variants than for Wuhan/D614G NTDs. We show that enhancing antibodies reinforce the binding of the spike trimer to the host cell membrane by clamping the NTD to lipid raft microdomains. This stabilizing mechanism may facilitate the conformational change that induces the demasking of the receptor binding domain. As the NTD is also targeted by neutralizing antibodies, our data suggest that the balance between neutralizing and facilitating antibodies in vaccinated individuals is in favor of neutralization for the original Wuhan/D614G strain. However, in the case of the Delta variant, neutralizing antibodies have a decreased affinity for the spike protein, whereas facilitating antibodies display a strikingly increased affinity. Thus, ADE may be a concern for people receiving vaccines based on the original Wuhan strain spike sequence (either mRNA or viral vectors). Under these circumstances, second generation vaccines with spike protein formulations lacking structurally-conserved ADE-related epitopes should be considered.