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Sperm Donor’s Rare TP53 Gene Variant Linked to Cancer in 10 of 67 Children Conceived
The use of donor sperm has helped countless individuals and couples realize their dream of parenthood. However, a recent alarming case has brought to light serious medical, ethical, and regulatory challenges linked to donor sperm use. A rare cancer-causing mutation in the TP53 gene was discovered in the sperm of a donor whose sperm was used to conceive at least 67 children across multiple…
Classification moléculaire des carcinomes de l’endomètre (OMS 2020).
Autres facteurs pronostics : si NSMP
Emboles : significatifs /substantiel si ≥ 5
Stade FIGO
Grade : uniquement si carcinome endométrioïde
Genetic Factors In Breast Cancer - Are You At Greater Risk?
Genetic Factors In Breast Cancer – Are You At Greater Risk?
Genetic Factors In Breast Cancer – Are You At Greater Risk?
Genetic factors have a significant role in breast cancer. Statistics shows that around 5% to 10% of breast cancer cases have a genetic component.
As researchers study more and more of the major diseases, such as heart disease and cancer, they are finding that many of them have a genetic component, that is, they run in families. The…
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Lung and prostate small cell carcinomas are driven by common mechanisms, which could lead to the development of one treatment for all small cell cancers.
Who would have thought prostate and lung cancers would have similarities in mechanisms? Check out this article describing how scientists found this link what it means for drug targeting (journal paper link within).
Li -Fraumeni Syndrome and Pancreatic Cancer
Li -Fraumeni Syndrome and Pancreatic Cancer
Li -Fraumeni Syndrome and Pancreatic Cancer
Author Column: Marzan Khan, B.Sc.
Li-Fraumeni syndrome (LFS) is a condition that makes individuals prone to developing a wide variety of cancers that occur early on in life, the most common types being- soft tissue sarcoma, osteosarcoma, breast cancer, brain tumors, adrenocortical carcinoma (ACC), and leukemia. (1) Pancreatic cancer is minimally…
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DNA修復の安全機構に関わるTP53やCHK2の機能喪失変異により，それぞれ網膜芽細胞腫39)，遺伝性非ポリポーシス大腸癌40－43)，Li-Fraumeni症候群44，45) が発症するなどである．
http://www.sasappa.co.jp/online/abstract/tkk/1/056/html/0710560101.html
p53とヒトのがん
