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5-Chlorosalicylaldehyde is mainly used as an intermediate in organic synthesis such as medicines, spices and dyes. So how is 5-Chlorosalicylaldehyde made?

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2-Amino-4-chloro-pyridine is widely used and can be used to prepare 4-fluoro-2-aminopyridine. The preparation method of 2-amino-4-chloro-pyridine is introduced below.

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2-Mercaptobenzimidazole is widely used, mainly used in synthetic rubber, cis-butadiene rubber, styrene-butadiene rubber, nitrile butadiene rubber, latex, etc.

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The leakage of 5-chloro-2-methylaniline will cause certain harm, so it is necessary to understand the treatment method of 5-chloro-2-methylaniline leakage.

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The leakage of 5-chloro-2-methylaniline will cause certain harm, so it is necessary to understand the treatment method of 5-chloro-2-methylaniline leakage.

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90-02-8|Precautions For The Use Of Salicylaldehyde-Supplier

Salicylaldehyde is an organic substance with the chemical formula C7H6O2, a colorless to yellow oily liquid with a burning and almond odor. Slightly soluble in water, soluble in organic solvents such as ether. Salicylaldehyde is a spice and a very versatile intermediate in organic synthesis. By the reaction of phenol and chloroform in sodium hydroxide solution.

Precautions for the use of salicylaldehyde1. Hazard overview

Health hazards: Salicylaldehyde is irritating to the respiratory tract, causing cough and chest pain after inhalation. Irritating to eyes and skin.

Explosion Hazard: Salicylaldehyde is flammable, toxic and irritating.

2. First aid measures

Skin contact with salicylaldehyde: Remove contaminated clothing and rinse skin thoroughly with soap and water.

Eye contact with salicylaldehyde: Lift eyelids and flush with running water or normal saline. Seek medical attention promptly.

Inhalation of salicylaldehyde: quickly leave the scene to fresh air. Keep the airway open. If breathing is difficult, give oxygen. If breathing stops, give artificial respiration immediately. Seek medical attention promptly.

Ingestion of salicylaldehyde: Drink plenty of warm water, induce vomiting, and seek medical attention in time.

3. Fire protection measures

Hazardous characteristics: Salicylaldehyde can easily burn and emit toxic gas when exposed to high heat, open flame and strong oxidant.

Hazardous combustion products: carbon monoxide, carbon dioxide.

Extinguishing method: Use water mist, foam, carbon dioxide, dry powder, sand to extinguish the fire.

4. Emergency treatment of salicylaldehyde leakage

Emergency treatment: quickly evacuate the personnel from the leaked contaminated area to a safe area, isolate them, and strictly restrict access. Cut off the source of ignition. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and protective clothing. Cut off sources of leaks as much as possible. Prevent flow into restricted spaces such as sewers and flood drains.

Small spills: Absorb or absorb salicylaldehyde with sand or other non-combustible materials. It can also be washed with plenty of water, diluted with the washing water and put into the waste water system.

Large spills: Construct dikes or dig pits for containment. Cover salicylaldehyde with foam to reduce vapor hazards. Transfer it to a tanker or a special collector with a pump, and recycle it or transport it to a waste disposal site for disposal.

5. Handling and storage of salicylaldehyde

Operation precautions: closed operation, provide sufficient local exhaust. The operation is as mechanized and automated as possible. Operators must undergo special training and strictly abide by operating procedures. It is recommended that operators wear self-priming filter respirators (half masks), chemical safety goggles, gas-penetrating respirators, and chemical-resistant gloves. Keep away from fire and heat sources, and smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent vapors from leaking into the workplace air. Avoid contact with oxidants, acids and bases. When handling, it should be lightly loaded and unloaded to prevent damage to packaging and containers. Equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Empty containers may be harmful residues.

Storage Precautions: Store salicylaldehyde in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep container tightly closed. Salicylaldehyde should be stored separately from oxidants, acids, alkalis, and edible chemicals, and should not be mixed. Equipped with the appropriate variety and quantity of fire equipment. Storage areas should be equipped with emergency release equipment and suitable containment materials.

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The synthetic method of dicyclopentadiene

Dicyclopentadiene (DCPC for short) is a dimer of cyclopentadiene. First heating is used to copolymerize cyclopentadiene into dicyclopentadiene, dicyclopentadiene Chemicalbook is separated from other light components (boiling point <45°C) by distillation, and then other required dienes, Monoolefin and saturated hydrocarbon components. High-purity dicyclopentadiene is a colorless crystal at room temperature. When it contains impurities, it is a light yellow oily liquid with a pungent camphor smell. It is insoluble in water and soluble in organic solvents such as alcohol and ether.

Distill the light benzene fraction of coal tar, cut out the benzene head fraction below 70°C, which contains about 30% cyclopentadiene, then heat, polymerize, and distill to obtain the finished product dicyclopentadiene. It is obtained from the C5 fraction in the hydrocarbon cracking industry as the raw material, which is heated and dimerized, and then separated by distillation under reduced pressure. Secondly, it can also be obtained by dimerization with cyclopentadiene as raw material. Process flow:

1. Using the C5 fraction as the raw material, firstly heat the C5 fraction to 80-120°C to dimerize the cyclopentadiene. Then, rectification is performed, and a dicyclopentadiene fraction is obtained by separation from the column bottom. Because in addition to cyclopentadiene, isoprene, etc., this fraction also contains diolefins. When it is heated to above 170℃, only dicyclopentadiene is preferentially decomposed and rectified. The obtained cyclopentadiene is thermally polymerized and rectified to obtain dicyclopentadiene.

2. Cyclopentadiene can be converted into dimer with a boiling point of 170°C by thermal polymerization, and then purified by distillation. The dimerization reaction was most complete at 70°C but the reaction process was very slow. Use heating under total reflux for 16-18h, and then heat up to take the front fraction (below 82°C) and the benzene fraction (above 82°C) until the kettle temperature reaches 110°C. The residue at the bottom of the kettle is dicyclopentadiene with a content of about 60%, and then through vacuum distillation, a dimer with a content of ≥99% can be obtained.

Clent Chemical is a company that sells dicyclopentadiene, our dicyclopentadiene is of good quality. If you want to learn more about dicyclopentadiene, please stay tuned to our website. We will regularly update relevant articles and products, and provide relevant product information and materials, and look forward to your visit and consultation.

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What kind of situation is suitable for citicoline?

Citicoline is a relatively inexpensive generic drug, which is an activator of brain metabolism, which can promote brain cell respiration, improve brain function, enhance the function of the activation system of the ascending reticular structure, promote awakening, and reduce cerebrovascular resistance.

The role and efficacy of citicoline are mainly used for the treatment of organic sequelae of the nervous system caused by brain injury and cerebrovascular accident. Citicoline itself is a brain metabolism activator, which can promote the nutrition and metabolism of brain nerve cells, improve brain structure and function, and enhance the conduction function of the reticular ascending activation system, which can promote recovery and reduce cerebrovascular resistance. Therefore, this drug is used for acute craniocerebral trauma, surgery, cerebral infarction, ischemic cerebrovascular disease, vascular dementia, acute poisoning, such as carbon monoxide poisoning, sleeping pill poisoning, alcohol poisoning, etc. Consciousness disorders, all have a certain degree of improvement.

Citicoline is suitable for use in the following situations:

1. Citicoline is mainly used for the disturbance of consciousness after acute craniocerebral trauma and brain surgery.

2. Citicoline can also be used for disturbance of consciousness in the acute phase of cerebral infarction.

3. Citicoline can be used for ischemic cerebrovascular disease, vascular dementia, tinnitus and neural deafness.

4. Citicoline can also be used for coma and disturbance of consciousness caused by acute poisoning, infection, and massive cerebral infarction.

5. Citicoline contributes to the recovery of upper and lower limb function in patients with stroke sequelae and post-stroke hemiplegia, and can be used together with drugs that promote cerebral metabolism and cerebral circulation. But only within one year after the onset, and in the cases of functional rehabilitation training and usual oral drug therapy (cerebral metabolism activator, cerebral circulation drug improvement, etc.), the lower extremity hemiplegia is relatively mild.

6. The following diseases can be treated with proteolytic enzyme inhibitors.

⑴ acute pancreatitis.

⑵ acute exacerbation of chronic recurrent pancreatitis.

(3) Postoperative acute pancreatitis.

Clent Chemical is the supplier of Citicoline, if you want to know more about Citicoline, please continue to pay attention to our website.

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Emergency treatment and disposal method of 3,5-lutidine

1. 3,5-lutidine leakage emergency treatment:

Quickly evacuate personnel from the leaked contaminated area to a safe area, isolate them, and strictly restrict access. Cut off the source of ignition. It is recommended that emergency personnel wear self-contained positive pressure breathing apparatus and fire protection clothing. Do not come into direct contact with spilled 3,5-lutidine. Cut off sources of leaks as much as possible. Prevent entry into restricted spaces such as sewers and flood drains. Small spill of 3,5-lutidine: Absorb with sand, vermiculite or other inert material. Collect and transport to an open place for burial, evaporation, or incineration. Large leakage of 3,5-lutidine: build embankments or dig pits for containment; cover with foam to reduce vapor hazards. Transfer it to a tanker or a special collector with an explosion-proof pump, and recycle it or transport it to a waste disposal site for disposal.

2. Protective measures:

Respiratory protection: Filter respirators (half masks) should be worn when exposure to its vapors is possible. It is recommended to wear air respirators during emergency rescue or evacuation.

Eye Protection: Wear chemical safety goggles.

Body Protection: Wear adhesive protective clothing.

Hand Protection: Wear rubber gloves.

Others: Smoking is strictly prohibited at the work site. After work is done, shower and change. Conduct pre-employment and regular physical examinations. Practice good hygiene.

3. First aid measures:

Skin Contact: Remove contaminated clothing and rinse skin thoroughly with soap and water.

Eye Contact: Lift the eyelids and flush with running water or normal saline. seek medical attention.

Inhalation: Quickly leave the scene to fresh air. Keep the airway open. If breathing is difficult, give oxygen. If breathing stops, give artificial respiration immediately. seek medical attention.

Ingestion: Drink enough warm water, induce vomiting, seek medical attention.

Clent Chemical is a 3,5-lutidine supplier, we sell 3,5-lutidine with guaranteed quality and reasonable price. If you want to learn more about 3,5-lutidine, please stay tuned to our website. We will regularly update 3,5-lutidine related articles, and provide 3,5-lutidine information and materials, and look forward to your visit and consultation.

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What is the synthesis method of 2-methylpyridine?

Like pyridine, 2-methylpyridine can form salts with inorganic or organic acids, and form addition compounds with inorganic salts and alkyl halides. During hydrogenation, α-methylpiperidine or pyridine can be obtained according to different conditions. The 2-position methyl group in 2-methylpyridine is highly reactive and generates pyridine-2-carboxylic acid (picolinic acid, C5H4NCO2H) when oxidized. In the presence of a dehydrating agent, it condenses with benzaldehyde to generate benzylidene derivatives. It reacts with paraformaldehyde at 200°C to produce 2-(β-hydroxyethyl) pyridine.

Pyridine and picoline are usually recovered from the by-products of coal coking. It is distributed in coke oven gas, crude benzene and tar. Generally, the boiling point of pyridine hydrates transferred from coal gas to ammonium sulfate mother liquor is very low. Between 95-97 ℃, the recovered crude light pyridine base contains about 15% of 2-picoline, which will be further rectified. Can be cut to obtain 2-methylpyridine. With the expansion of the use of pyridine and picoline, the production of pyridine and picoline by synthetic methods continues to develop. About 95% of pyridine and pyridine compounds abroad are produced by synthetic methods. The main synthetic methods are acetaldehyde method, acetylene method, acrylonitrile method and so on.

1. Acetaldehyde method: the reaction of acetaldehyde, formaldehyde and ammonia, the main products are 2-methylpyridine, 3-methylpyridine and 4-methylpyridine.

2. Acetylene method: Acetylene reacts with ammonia, and the main products are 2-methylpyridine and 4-methylpyridine.

3. Ethylene method: the reaction of ethylene and ammonia, the main products are 2-methylpyridine and 2-methyl-5-ethylpyridine.

4. Acrylonitrile method: Acrylonitrile reacts with excess acetone, and the main product is 2-methylpyridine. In addition, the reaction of acrolein and ammonia mainly produces 3-methylpyridine.

Clent Chemical is a supplier of 2-methylpyridine. The quality of 2-methylpyridine we sell is guaranteed and the price is reasonable. If you want to know more about 2-methylpyridine, please continue to pay attention to our website. We will regularly update related articles and products, and provide related product information and materials, and look forward to your visit and consultation.

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What is the 3-Mercaptopropionic acid?

3-Mercaptopropionic acid is an organic substance with a chemical formula of C3H6O2S. It is a transparent liquid with a strong smell of sulfide, smelly and toxic. 3-Mercaptopropionic acid is an intermediate of pharmaceutical fennerol and also used as a stabilizer for polyvinyl chloride.

Uses of 3-mercaptopropionic acid:

3-Mercaptopropionic acid is an intermediate of pharmaceutical fennerol and also used as a stabilizer for polyvinyl chloride. 3-Mercaptopropionic acid, like thioglycolic acid, can be used in transparent products with very good thermal stability, which is better than other stabilizers. 3-Mercaptopropionic acid is also used as an antioxidant, catalyst and biochemical reagent.

Production method of 3-mercaptopropionic acid:

3-Mercaptopropionic acid is prepared with acrylonitrile and thiourea as raw materials. First react thiourea with hydrochloric acid at 40°C for 0.5h, add acrylonitrile dropwise, react at 110-113°C for 3h, cool to 40°C, add 4% sodium hydroxide solution to pH 11, dehydrogenate at 30 Neutralize with hydrochloric acid at ℃ to a pH of 1-2. Then add benzene for extraction, recover the benzene and perform vacuum distillation, collect the 125-140°C fraction to obtain the finished product of 3-mercaptopropionic acid. In addition, 3-mercaptopropionic acid can also be prepared by reacting hydrogen sulfide with pyruvic acid or β-propiolactone.

3-Mercaptopropionic acid transportation and storage method:

3-Mercaptopropionic acid should be stored in a cool, ventilated warehouse. Keep away from fire and heat sources. It should be stored separately from oxidants, reducing agents, and alkalis, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. The storage area should be equipped with leakage emergency treatment equipment and suitable storage materials.

Clent Chemical is a supplier of 3-mercaptopropionic acid. We have professional technology to ensure product quality. If you want to know more about 3-mercaptopropionic acid, please continue to pay attention to our website. We will regularly update 3-mercaptopropionic acid related articles and information, and look forward to your visit and consultation.

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Usage and synthesis of 2-aminothiazole

2-Aminothiazole is white or light yellow crystals. The melting point is 93°C and the boiling point is 140°C (1.47kPa). It is soluble in hot water, dilute hydrochloric acid and 20% sulfuric acid, and slightly soluble in cold water, ethanol and ether.

Uses of 2-Aminothiazole: 1. 2-Aminothiazole is used as a pharmaceutical intermediate for organic synthesis. 2-Aminothiazole is mainly used in the synthesis of Nitrosulfathiazole, Sulfathiazole, Sulfasuxidinum, Carbothiazol, Phthalylsulfathiazole, Oxyquinolinephthalysulfathiazole ), Salazosulfathiazole (Salazosulfathiazole)

2. 2-Aminothiazole is used for gentle Ulmann coupling reaction with 2-chlorobenzoic acid under the guidance of ultrasonic radiation

3. 2-Aminothiazole is used as a pharmaceutical and dye intermediate

Production method of 2-aminothiazole: 2-Aminothiazole is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloro ethyl ether). Add hot water, thiourea and α, β-dichloroethyl ether to the reactor. Reflux for 2h under stirring. After cooling, sodium hydroxide solution was added through the dropping funnel to make the solution alkaline and 2-aminothiazole crystals were precipitated. Then add ether to dissolve it. Separate the ether layer, wash with water, dry with anhydrous sodium sulfate, and distill the ether to obtain a crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80%, and the melting point is 90°C.

Toxicity classification: Highly toxic acute toxicity oral-rat LD50: 480 mg/kg; intraperitoneal-mouse LD50: 200 mg/kg

Hazardous characteristics of explosives: its nitric acid mixture; or its nitric acid-sulfuric acid mixture heating and exploding

Flammability and hazard characteristics: 2-Aminothiazole is combustible; high temperature produces toxic nitrogen oxide and sulfur oxide fumes

Storage and transportation characteristics: The warehouse is ventilated, low temperature and dry; stored separately from nitric acid and sulfuric acid

Extinguishing agent: dry powder, foam, sand, carbon dioxide, water mist

Clent Chemical is a supplier of 2-aminothiazole, we have professional technology to ensure product quality. If you want to know more about 2-aminothiazole, please continue to pay attention to our website. We will regularly update articles and information related to 2-aminothiazole, and look forward to your visit and consultation.

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What is the use and synthesis method of 2-aminothiazole?

2-Aminothiazole is a white or light yellow crystal with a melting point of 93°C and a boiling point of 140°C (1.47kPa). It is soluble in hot water, dilute hydrochloric acid and 20% sulfuric acid, and slightly soluble in cold water, ethanol and ether. It is an important chemical raw material and a synthetic intermediate for medicines, dyes, water purifiers, etc. It is widely used in the synthesis of third and fourth generation cephalosporins.

Uses of 2-Aminothiazole:

1. Used as a pharmaceutical intermediate. Used in organic synthesis;

2. Mainly used in the synthesis of Nitrosulfathiazole, Sulfathiazole, Sulfasuxidinum, Carbothiazol, Phthalylsulfathiazole, Oxyquinolinephthalysulfathiazole, Salazosulfathiazole (Salazosulfathiazole);

3. It is used for gentle Ulmann coupling reaction with 2-chlorobenzoic acid under the guidance of ultrasonic radiation;

4. Used as intermediates of medicine and dyestuffs in Medical Chemicalbook.

Production method of 2-aminothiazole:

2-Aminothiazole is obtained by cyclization of thiourea and chloroacetaldehyde (or ethanol and chlorine, or α, β dichloro ethyl ether). Add hot water, thiourea and α, β-dichloroethyl ether to the reactor. Reflux for 2h under stirring. After cooling, sodium hydroxide solution was added through the dropping funnel to make the solution alkaline and 2-aminothiazole crystals were precipitated. Then add ether to dissolve it. Separate the ether layer, wash with water, dry with anhydrous sodium sulfate, and distill the ether to obtain a crude product. Recrystallize with ethanol to obtain yellow crystals. The yield is 80%, and the melting point is 90°C.

2-Aminothiazole storage method:

2-Aminothiazole needs to be stored in a cool, ventilated warehouse. Keep away from fire and heat sources. Keep the container tightly closed. It should be stored separately from oxidants, acids, and edible chemicals, and avoid mixed storage. Equipped with the appropriate variety and quantity of fire equipment. The storage area should be equipped with suitable materials to contain the leakage.

Clent Chemical provides 2-aminothiazole wholesale, strict quality inspection to ensure product quality. If you want to know more about 2-aminothiazole, please continue to pay attention to our website. We will update relevant articles and products from time to time, and provide relevant product information and materials, and look forward to your visit and consultation.

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Emergency measures for Indole-3-carbinol leakage

Indole-3-carbinol is produced by the decomposition of glucosinolates, which is relatively high in cruciferous vegetables, such as broccoli, cabbage, cauliflower, Brussels sprouts, kale and kale. Improper storage and operation of indole-3-carbinol may lead to leakage of indole-3-carbinol. Once indole-3-carbinol is leaked, what should we do to minimize the loss?

Emergency treatment for leakage of indole-3-carbinol: Emergency procedures for protective measures for workers: 1. It is recommended that emergency handlers wear air-contained breathing apparatus, anti-static clothing, and rubber and oil-resistant gloves. It is forbidden to touch or cross over the leakage.

2. All equipment used during operation should be grounded.

3. Cut off the source of leakage as much as possible.

4. Eliminate all ignition sources.

5. Delimit the warning zone according to the influence area of liquid flow, steam or dust diffusion, and unrelated personnel should be evacuated from the crosswind and upwind to the safe zone.

6. Contain leaks to avoid environmental pollution. Prevent leaks from entering sewers, surface water and groundwater. The containment and cleaning methods of the leaked chemicals and the disposal materials used: small amount of leakage: collect the leaked liquid in a sealable container as much as possible. Absorb with sand, activated carbon or other inert materials, and move to a safe place. Do not flush into the sewer. A large number of leaks: construct a dike or dig a pit for storage. Close the drainage pipe. Cover with foam to prevent evaporation. Use explosion-proof pump to transfer to tank truck or special collector, recycle or transport to waste disposal site for disposal.

Handling and storage of indole-3-carbinol: Precautions for the operation of indole-3-carbinol: 1. Operators should be specially trained and strictly abide by the operating procedures.

2. Operation and disposal should be carried out in a place with local ventilation or comprehensive ventilation facilities.

3. Avoid contact with eyes and skin, and avoid inhaling steam.

4. Keep away from fire and heat sources, and smoking is strictly prohibited in the workplace.

5. Use explosion-proof ventilation system and equipment.

6. If canning is required, the flow rate should be controlled, and there should be a grounding device to prevent static electricity from accumulating.

7. Avoid contact with incompatible materials such as oxidants.

8. When handling, load and unload with care to prevent damage to packaging and containers.

9. The emptied container may leave harmful substances.

10. Wash hands after use and prohibit eating or drinking in the workplace.

11. Equipped with corresponding types and quantities of fire-fighting equipment and leakage emergency treatment equipment.

Precautions for storage of indole-3-carbinol: 1. Store in a cool, ventilated warehouse.

2 It should be stored separately from oxidants and edible chemicals, and avoid mixed storage.

3. Keep the container tightly closed.

4. Keep away from fire and heat sources.

5. The warehouse must install lightning protection equipment.

6. The exhaust system should be equipped with a grounding device to remove static electricity.

7. Use explosion-proof lighting and ventilation settings.

8. It is forbidden to use equipment and tools that easily produce sparks.

9. The storage area should be equipped with leakage emergency treatment equipment and suitable storage materials.

The above are the emergency measures for the leakage of indole-3-carbinol and the precautions for storage of indole-3-carbinol. As a manufacturer of indole-3-carbinol, Clent Chemical has a professional production experience team, and its products are reasonably priced and have won unanimous praise from customers. If you want to know more about indole-3-carbinol, please continue to pay attention to our website.

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How is pyrroloquinoline quinone prepared?

High cell density fermentation (HCDF) has been developed in the last decade or two. It is a new type of fermentation technology that uses certain culture techniques and equipment to increase the ratio of bacterial biomass to target products and obtain high metabolites.

High cell density fermentation is currently reported in the following application areas: first, the use of engineered bacteria to produce various interferons, growth factors, biological enzymes, peptides, polysaccharides and other active ingredients; second, the application of high cell density fermentation technology in the food industry For the cultivation of living cells; the third is for yeast production of alcohol and the use of spirulina cells to produce spirulina. Due to the limitation of fermentation technology and equipment, there is no report on the industrial production of PQQ yet.

Steps to improve PQQ productivity:

CN201810866397.0 provides a method for high-density fermentation to increase the yield of PQQ, which shortens the fermentation period and improves the yield of PQQ. The method for increasing the yield of PQQ by high-density fermentation includes the following steps:

(1) Strain activation: Connect the hyphomicrobial strains to the slant culture medium, and obtain mature slant strains after cultivation;

(2) Preparation of seed mother liquor: the mature slant strain prepared in step (1) is inoculated into a seed culture medium and cultured on a shaker to obtain seed mother liquor;

(3) Seed pot culture: Use a 1.5-2m seed pot, add pure water to 50-60% of the volume of the seed pot, calculate the required seed pot culture material and add all the seed pot culture materials except anhydrous methanol while stirring. After the raw materials are completely dissolved and evenly dispersed, the volume is adjusted to 60-65% of the volume of the seed tank with purified water, mixed evenly, and the pH is adjusted to 7.0. After the seed tank is sterilized, it is cooled to 25-35°C, and the sterile filtered water is added. Mix evenly with water and methanol. Put the seed mother liquor obtained in step (2) into the seed tank, control the tank pressure at 0.08-0.10MPa, the tank temperature at 30-35°C, the air flow rate at 0.8-1.0VVM, and the pH at 6.8-7.0. Ventilate and stir for 42-50 hours to form a seed tank culture solution;

The seed pot culture material added to every 1.5m seed pot includes the following weights of raw materials:

(4) The initial preparation of the fermenter: use a fermenter of 20m or more, add purified water to 30-40% of the volume of the fermenter, add the fermenter culture material while stirring, and after the raw materials are completely dissolved and dispersed, use pure water to make the volume to 40-50% of the volume of the fermentor, mix well, adjust the pH to 7.0, and cool the fermenter to 25-35℃ after sterilization, and use sterile air to fill the seed tank obtained in step (3) with the inoculation ratio of 10-20% Press the culture broth from the seed tank into the fermentor, control the initial pressure of the fermenter to be 0.08-0.10MPa, the initial flow rate is 0.8-1VVM, the initial stirring speed is 110-130rpm/min, and the initial temperature is 30℃; bring it from the seed tank into the fermentor Unused anhydrous methanol is used as the initial concentration of methanol in the fermentation tank;

The fermenter culture material added to every 20m fermentor includes the following weights of raw materials:

(5) Fermentation and cultivation and feeding: before fermentation, add purified water and glycerin to the feeding tank, add sterile filtered anhydrous methanol after sterilization, and mix evenly to form feeding; during the fermentation process, when in the fermentation tank When the methanol concentration drops to 1000-1500ppm, start feeding to keep the total concentration of methanol and glycerin in the fermentor at 1000-1500ppm. Fermentation and cultivation are carried out for 5-6 days while feeding to obtain a high-content fermentation broth of PPQ.

The above is the introduction of the method steps for high-density fermentation to increase the yield of PQQ. PQQ can improve the metabolism and growth function of biological tissues and improve the immune function of the human body, which has high value. As a PQQ supplier, Clent Chemical has rich production experience and a professional production team, and the product quality is guaranteed. If you want to know more about PQQ, please continue to pay attention to our website.

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How to handle and store 2,3 dihydrofuran?

2,3 dihydrofuran is a chemical substance and an important raw material for pharmaceutical chemicals. When we operate 2,3 dihydrofuran, we must strictly abide by the operating procedures. The following editor will give you a detailed introduction to the handling and storage precautions of 2,3 dihydrofuran. I hope to be helpful.

Operation precautions:

1.Operators should be specially trained and strictly abide by the operating procedures.

2.Operation and disposal should be carried out in a place with local ventilation or comprehensive ventilation facilities.

3.Avoid contact with eyes and skin, and avoid inhaling steam.

4.2,3 dihydrofuran is far away from fire and heat sources, and smoking is strictly prohibited in the workplace.

5.Use explosion-proof ventilation system and equipment.

6.If the 2,3 dihydrofuran needs to be canned, the flow rate should be controlled, and there should be a grounding device to prevent the accumulation of static electricity.

7.2,3 dihydrofuran avoid contact with oxidants and other incompatible materials.

8.When handling 2,3 dihydrofuran, load and unload with care to prevent damage to the packaging and container.

9.The emptied container may leave harmful substances.

10.Wash hands after use and prohibit eating or drinking in the workplace.

11.Equipped with corresponding types and quantities of fire-fighting equipment and leakage emergency treatment equipment.

Storage precautions:

1.2,3 dihydrofuran is stored in a cool, ventilated warehouse

2.2,3 dihydrofuran should be stored separately from oxidants and edible chemicals, and should not be mixed.

3.Keep the container tightly closed.

4.Keep 2,3 dihydrofuran away from fire and heat sources.

5.The warehouse must install lightning protection equipment.

6.The exhaust system should be equipped with a grounding device to remove static electricity.

7.Use explosion-proof lighting and ventilation settings.

8.It is forbidden to use equipment and tools that easily produce sparks.

9.The storage area should be equipped with leakage emergency treatment equipment and suitable storage materials.

As a 2,3 dihydrofuran company, Clent Chemical has rich production experience and a professional production team, and the product quality is guaranteed. If you want to know more about 2,3 dihydrofuran, please continue to pay attention to our website. We will update relevant articles and products from time to time, and provide relevant product information and materials, and look forward to your visit and consultation.

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Application of pyrroloquinoline quinone

The scientific name of PQQ is pyrroloquinoline quinone, which is a new prosthetic group that can treat heart disease, neurological diseases, protect the liver, and maintain mitochondrial function. Pyrroloquinoline quinone widely exists in prokaryotes, plants and mammals. It is not only the prosthetic group of many enzymes, but also the function of transferring electrons, protons and chemical groups in enzymatic reactions, and can also stimulate microorganisms. The growth of plants, the germination of plant pollen, promote the growth of plants.

Pyrroloquinoline quinone biological function: The main biological functions of PQQ include: stimulating the rapid growth of microbes, plants, animals and human cells; removing excess free radicals in the body; stimulating the production of nerve growth factor; protecting mammalian cardiomyocytes. Its efficacy: an important growth factor in the body; regulating the level of free radicals in the body, protecting the body; anti-oxidant damage; enhancing mitochondrial function; detoxification; preventing skin aging, weakening melanin deposition disorders; preventing Parkinson's disease; preventing Alzheimer's disease, etc.

Pyrroloquinoline quinone application: Allicin is a broad-spectrum antibacterial drug with strong antibacterial, anti-inflammatory, blood pressure lowering, blood lipid lowering and other biological functions; and pyrroloquinoline quinone (PQQ), as an essential factor for human development, can stimulate the growth of human cells Growth, especially activating human B cells and T cells to produce antibodies and improve the body’s immune function. Pyrroloquinoline quinone (PQQ) is the most potent biologically active substance discovered by humans so far, which can comprehensively improve human immune function.

CN201610311618.9 Due to the clever application of pyrroloquinoline quinone (PQQ) and allicin in the treatment of neurodermatitis and eczema, the pyrroloquinoline quinone (PQQ) and allicin cooperate with each other to kill pathogenic bacteria , Anti-inflammatory, and joint conditioning of skin nerve function, while also improving the body’s immunity, so that the patient’s pathogenic bacteria in the patient’s body will be killed after external use of the drug with pyrroloquinoline quinone (PQQ) and allicin in the present invention At the same time, the patient’s immunity can be greatly improved, the skin nerve function can return to normal, and the invasion of other pathogenic bacteria can be prevented, so that the patient’s neurodermatitis and eczema can be cured, and the recurrence can be effectively prevented; therefore, The invention has the advantages of killing pathogenic bacteria and jointly regulating the skin nerve function, while also improving immunity, and at the same time, it has the advantages of almost no side effects on patients and good curative effect.

Pyrroloquinoline quinone (PQQ) has a reversal effect on the multidrug resistance of lung cancer/cisplatin-resistant strains (A549/DDP) and ovarian cancer/paclitaxel-resistant strains (A2780/Taxol).

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