★
noise dept.
❣ Chile in a Photography ❣
Phantogram Three
I'd rather be in outer space 🛸
YOU ARE THE REASON
tumblr dot com
Sweet Seals For You, Always
cherry valley forever
almost home
hello vonnie
ojovivo
bliss lane
$LAYYYTER
if i look back, i am lost
RMH
Interview Vampire Daily
Origami Around
🩵 avery cochrane 🩵
Monterey Bay Aquarium
seen from Türkiye
seen from Portugal
seen from Germany
seen from T1
seen from Uruguay
seen from United States
seen from Japan
seen from United States
seen from Ecuador
seen from Brazil
seen from United States
seen from Indonesia
seen from United States
seen from Brazil
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seen from United States
@ookumspookumswastakensomehow
Ive been saying this to “liberal” friends who say shes too loud.
Let her be. Queens and the bronx love her for it.
man, us lefties all over the place love her for it.
I mean to be fair it seems like a few of the REALLY savvy career Dems are aware of this, but yeah I’ve been super unimpressed by how many don’t seem to grasp it.
DSBKGFSBKRJSEKGFBAKESDHCGFASJHYEFJGDE
Did everyone just…. forget how to create, all of a sudden? Disney pumping out the fourth remake in a row? Movies are like 70% sequels? Stories in games being just bad if they exist at all? Haven’t had a book get hyped in like half a decade? Are we okay? What’s going on?
#look to indie creators #creativity isnt dead its being held captive behind a wall of capitalism and greed #huge corporations are only willing to make what they know will already sell
awkward how reassuring i find this
well ya duh society shames speech patterns associated with young women
“Speech fillers” are just a human’s way of saying “wait a sec I’m thinking”. It means we think more before we speak, always trying to find the right way to say it. Every language has them. And people shouldn’t be annoyed by it, ever.
Fun fact: even Deaf people and ASL users have a “filler” and depends on the person. Sometimes it’s almost like a wave, other times it’s wiggling fingers.
The difference between a large and small beer at Applebee’s
wow i love this
One of the truest things I’ve ever heard is that people who say they’re “brutally honest” are more interested in the brutality than the honesty.
countries where prostitution is legal have higher rates of human trafficking. that’s like an actual fact. not an opinion or anything. so tbh it seems a bit ‘swerfy’ to completely ignore that
speaking, uh, as a formerly-trafficked sex worker, it’s extremely difficult to come forward as a trafficking victim in countries where sex work is criminalized; you just… get criminalized under those same anti-prostitution laws. of course reported trafficking would increase when the sole fact of coming forward as a sex worker at all no longer endangers you.
This line of argument is the same one that you see with conservatives who point to the increase in divorce rates as proof that making divorce safer is endangering marriage, while ignoring the massive drops in domestic abuse, murder, and suicide.
It’s a shot argument with them, and it’s a shot argument here.
In WWI, when they introduced helmets, they saw a sudden spike in head injuries.
What the casual observer may miss was that they were seeing the increase because of a dramatic decrease in deaths from head wounds.
Say it with me now:
CORRELATION, NOT CAUSATION
There has also been a recent spike in:
- vaccine induced polio
- seatbelt injuries
As the result of a recent decline of:
- natural polio
- asphalt injuries
new ebbits! new site!
this is probably my favourite comic of all time jsyk
can someone explain this to me?
Sure thing! For convenience I’ll refer to the guy with his arms in his pockets as SG (shorter guy) and the one on the computer as TG (taller guy).
In the first panel, SG sees TG playing on the computer and is disappointed. SG puts a lot of value in the idea of “making things,” specifically “art,” and thinks TG is just wasting their time
So he asks them if they wouldn’t rather be “making something” instead of just playing games and listening to music, implying that TG isn’t doing anything worthwhile or creative with their time
But TG replies that “interpreting is generative,” meaning that even if they spend their time just doing fun stuff, the mere act of enjoying something is creating an experience and an interpretation. Talking about something, dancing to music or sharing a piece of art with your friends IS “making something,” and each of those can be worthwhile and artistic.
SG leaves, complaining he “can’t be an auteur of [interpretation].” Auteur is a movie term that refers to a filmmaker with artistic control and vision enough to be considered essentially the singular creator of the resulting work of art. Turns out, SG doesn’t just want to “make things,” he wants to make things he and others see as “important.” He wants to make art not for the sake of art, but for the sake of being recognized and praised for his art.
This comic really speaks to elitism within the artistic community, the idea that art needs to meet certain standards to be considered art. SG’s viewpoint is really traditionalist, that art need to be “approved” and validated in order to be considered “really art;” while TG recognizes that art can be as little as just talking about what you love.
TLDR: Art is for everyone, not just some sort of social “artistic elite.”
ooh i love the explanation
New footage of animatronics for Tokyo Disneyland’s new Beauty and the Beast attraction, and…
Oh my gosh, IT’S NOT SCREENFACES!!! :D
- Mod Rat
Weirdly anti-millennial articles have scraped the bottom of the barrel so hard that they are now two feet down into the topsoil
its so wild like “this generation with no fucking money is learning to prioritize essentials” and all these chucklefucks can write is advertisements for these companies
at least our jeans won’t tear at the seams after two washes
FUCK FABRIC SOFTENER IT’S UTTERLY POINTLESS
AND FUCK DRYER SHEETS LITERALLY NOBODY EVER HAS ENOUGH OF A PROBLEM WITH STATIC TO WARRANT PAYING OUT THE ASS FOR THAT SHIT
DO YOU WANT CLEAN CLOTHES? YOU DON’T EVEN NEED TO BUY FUCKING DETERGENT JUST MAKE YOUR OWN* IT’S SO GODDAMN EASY AND 80X CHEAPER
FUCK THE ENTIRE LAUNDRY INDUSTRY *Fuck The Entire Laundry Industry Recipe
1 cup Washing Soda (not Baking Soda. Different things.)
1 cup Borax (not Boric Acid. Also a different thing.)
½ cup - 1 cup grated bar soap (you can use literally anything. I often use Ivory because it’s easy to get and I find it works well, a lot of people like Fels-Naptha, which is an actual laundry bar. Some people use Dr. Bronner’s. Really does not fucking matter.) After grating your soap, combine all ingredients. That’s it. That’s the whole thing. Use maybe a ¼ cup per load.
^^^ I’ve done this for years now and it works as well as any store bought detergent
WHAT Thank you, tumblr user awfullydull! Your URL does no justice to the good advice you give!
Also you can MAKE your own washing soda very VERY cheaply.
Step one: acquire $5 bag of baking soda from Costco.
Step two: lay that motherfucking baking soda out on a baking tray.
Step three: bake the baking soda on a tray in an oven at 400° for 1 hour (to make the moisture evaporate, leaving washing soda)
Step four: revel in how easy and cheap it is to make your own washing soda, and maybe take a moment to be angry that the industry upcharges the fuck out of something that is so easy to make.
I see some of y'all complaining about static and/or wanting nice smelling laundry. Go to a craft store, find 100% wool yarn balls. If it doesn’t come in a ball, ask an employee to make it into a tight ball for you. Wash in the washing machine to make it felted. Remove from washer, add a few drops of essential oil to the ball, allow to seep in. Dry with clothing. Doesn’t need to be rewashed ever, and if it stops smelling, add few more drops of essential oil. Bam, reusable dryer sheets.
I love this post so much it’s filled with helpful advice, hatred, saving money, and fucking the system all in one
fanfic: this character has had several bottles of hard liquor and they’re just slurring their speech slightly and for some reason are not in the hospital with alcohol poisoning
me: ….you’ve literally never had a drink in your life have you
very good point. Alcohol For the Non-Drinking Fanfic Writer, a primer by me There’s a shit ton of variability in response to alcohol depending on body mass, history of drinking (your liver can upregulate the CYP450 enzyme responsible for metabolizing alcohol but only to a certain point; chronic alcoholics hit a point where their livers are so trashed they lose this and go back to getting drunk off small amounts of alcohol), and ethnicity (people of East Asian descent are more likely to lack a critical enzyme for breaking down one of the metabolic steps in the degradation of ethanol and are stuck in the shittiest part of it, with flushing and nausea), and other factors. But if I had to guesstimate for writing:
1 drink (a tall glass of beer, a can of beer, or a shot of hard alcohol in a cocktail or alone): are you a burly dude? you may or may not feel it. are you a tiny lady? you will probably notice it.
2 drinks: burly dude may or may not be noticing it. tiny lady like me: this is a sweet spot where you’re talkative but not drunk. (Note: people don’t go from zero to “so drunk you remember nothing/are profoundly disinhibited.” There’s a lot of ground to cover in between.)
3 drinks: burly dude probably feeling it, tiny lady getting drunk.
4 drinks: burly dude still feeling it, tiny lady ready to FUCKING FIGHT YOU
5 drinks: burly dude, slow down, buddy, you gonna polish off that six-pack by yourself? That’s going to hurt in the morning. Tiny lady: oh my GOD stop. Go to bed.
This is where we draw the cut-off for a “binge,” if you were wondering. More than this and you’re officially binge-drinking, where your odds of serious harm go up sharply. From alcohol, but also from the bad decision dinosaur that plagues you when you binge-drink.
a fifth of anything by yourself: Sir. Sir, can you hear me? Sir, I need you to open your eyes. Squeeze my fingers. Sir, you’re in the emergency room.
Splitting a bottle of wine between two adults: generally like three drinks each, you’ll feel it but you’ll survive. (A bottle of wine between three adults: usually not quiiiiiite enough.)
An entire bottle of wine by yourself: oh, so you enjoy suffering?
Other Fun Medical Alcohol Facts: high-proof alcohol like vodka will temporarily paralyze your pyloric sphincter, so the alcohol can’t get into your gut for about twenty minutes. Then, when it DOES get into your small intestine, enjoy getting uncomfortably drunk too fast.
Alcohol is a zero-order metabolizer: that means that nothing on Earth can sober you up except time*, and the time it takes is linear, directly related to how much you drank. Most of us can clear about a drink an hour, so if you’re drinking slowly you can stay roughly sober all day. Most of us don’t drink that slowly. Hangovers are made awful by a metabolic intermediate (literal acid in your blood!!!! it’s so shitty!!!!!!!) that makes you nauseated and feel super gross, and not every drinking episode will lead to a hangover, and severity of hangover varies greatly by person and amount drunk.
So please never write someone having coffee to “sober up.“ Now they’re drunk AND they can’t sleep. Bad combo. Sucks for driving. Splashing cold water on your face? No. Amphetamines? Good Lord what’s wrong with you. Look, the room’s gonna spin, you fucked up your endolymph in your semicircular canals, deal with it. You can partially override that with proprioceptive feedback–keeping one foot on the floor to get tactile input–but it’s just gonna suck for a while.
The variability in capacity is real; my aunt-in-law, who is roughly my size, can drink me under the table easily. She’s a high-powered business executive who has martinis with lunch. I tried to keep up with her once and had to call in sick. So you don’t HAVE to write a character having a “normal” alcohol tolerance, but don’t get into “yep, definitely alcohol poisoning” territory, please.
This has been Please Don’t Show Up In My Emergency Room, I Hate Getting Barfed On by your local friendly medical trainee.
*this is technically not true, but no substance you can get your hands on will do it. hmu if you want to hear the story of the EtOH receptor antagonist and why it never went to market, what with all the dying.
what’s the EtOH receptor antagonist???
okay whew. here we go. there has been a LOT more interest in this than I was expecting (I was expecting none, to be clear), and it has been approx. 8 billion years since I was in undergrad, which is the last time I can reasonably claim to have been CURRENT on Neuro research. (I did my master’s at an institution that does not have what one might call a robust Neuro department and mainly did Stats.) So if a real live Neuro person comes on here and contradicts me, you should probably believe them.
BUT. Here is the story, as I recall it:
Alcohol, or, as we fancy-schmancy-pantsy medical types like to call it to distinguish it from the bajillion other alcohols out there (”alcohol” describes a general type of molecule in chemistry, not the good ol’-fashioned Get You Drunk molecule) ethanol, abbreviated EtOH, is what’s generally called a “sedative-hypnotic.” What that means is that it doesn’t work on opioid receptors, it doesn’t work on cannabinoid receptors. It does stuff to your GABA receptors–GABA being the major inhibitory neurotransmitter–and it also binds to other stuff. We still don’t have its actions in the brain fully mapped. But we know, and we’ve known for a while, that it does stuff to GABA receptors.
A major pharmaceutical company developed an honest-to-God antagonist. If you’re not a pharm person, you may be going, “a what now?” First point: damn near everything your brain does is determined by neurotransmitters and the receptors that love them. Neurotransmitters interact with their receptors in a variety of ways, with a HUGE variety of end results. Humans love jamming other chemicals that are not neurotransmitters into their receptors. Why do opioids work? Because they mimic NTs we make ourselves. Why does cannabis get us high? Because it mimics endogenous (”originating inside”, self-made) NTs. Manmade molecules that alter us are hijacking built-in systems. Don’t even get me started on how fucking bananas cool it is that neurons can adapt to neurotransmitter levels, and in a super awesome sci-fi-like variety of ways. Take a Neuro class! Take five! Take seventeen! Most fun I ever had was in a Neuro lab.
So what’s an antagonist? It’s something that, one way or another, makes it so the NT can’t do its thing at the receptor.
The line of thinking went, if we can keep ethanol from doing its thing at the GABA receptor, we can make people sober again. They can drink and then take a pill and be sober. Wouldn’t that be AMAZING? Wouldn’t that be lucrative? These are questions that drug companies think about a LOT.
So they made the chemical! Its name is Ro15-4513. You can Google it and get a WAY less interesting description of what went down. But how my professor explained it to us is like this:
It works. It’s an ethanol antagonist at the GABA receptor. You take it and it blows the ethanol off the receptor and you’re sober. And… because humans are awful, you get drunk again. You take another pill. You’re sober again. The time that pill is active is less than the time it takes your body to metabolize ethanol, so you’ve still got all that ethanol swishing around in your system waiting to murder you via aspirating your own vomit the hot second it wears off, but by God, you’re sober.
Except, as mentioned, the GABA receptor is not the only place where ethanol does stuff. One of the effects it has, since it’s such a teeny tiny molecule, is fucking with the lipid bilayer that forms the bulk of your cell membrane. If you’re a Neuro person, you’re getting cold chills right about now, because the only reason neurotransmission works is the properties of the lipid bilayer. You have to be able to transmit electricity down the axon of the neuron to generate an action potential. The lipid bilayer is what allows you to do that.
The pill does nothing for that. So if you take enough of the pill, and keep drinking, there comes a point where you’ve fucked the lipid bilayer beyond repair. You can’t transmit messages. Your brain doesn’t remember how to tell your body to do things like breathe, or not have seizures. And you die!
So, in summary, we have a pill that could make you a responsible designated driver, but actually fucking kills you because people have no self-control.
Moral of the story: Neuroscience Is Super Fun!!!!! It was my gateway drug into medicine. I would never have gone to medical school if it weren’t for my Behavioral Neuroscience professors.
today on: humanity’s hubris has led to so many things being bad when they were designed to be good
tide pods are absolutely an aperture science invention. blue, orange, and white color scheme? pleasing rounded plastic aesthetic? look tasty but will burn your throat and kill you? i bet they were cave johnson’s attempt at creating delicious snack packs
“Cave Johnson here,
So I have some bad news and some good news, the bad news is those Aperture Science confectionaries we just spent millions of dollars making are absolutely toxic, they will rupture your insides immediately upon ingesting them. The good news is we’ve found they’re great for taking stains out of clothes.”
People with low income literally depend on dollar stores..
Activist investor is the weirdest thing I’ve read in a while
Dollar trees, dollar generals, family dollars’, ect. are dispersed all throughout big and small towns so they’re easily accessible. Not only do they have toiletries, basic household items, cheap snacks, cheap basic toys, office supplies, and cleaning tools ;most of the things in these stores are not luxury items. They are usually essential items to maintaining a clean and modest life.
It would be one thing if this were just some candy store or something but this is a store people rely on to keep their children fed and maintain a household.
How could anyone not want these items to be as accessible as possible???
They also have cheap fun items for children which can be very important. It’s a place where kids could get toys and activities they might not have normally been able to afford. Some family dollars even have clothes and school uniforms for cheap.
Dollar Tree is also so far the only store I have so far seen with dollar in the name where everything is actually a dollar
“activist” is a strange way to say “guy who wants more money out of poor people for literally nothing.”
We pick up snacks, bread, and stuff at dollar tree. Also cold meds on the cheap. I get some of my healthier snacks there like freeze dried strawberries and such. For like $20 Rattles and I can get a collection of snacks for a week and some extra things. We also get fun little things there like our little solar plant buddy Jeffery etc.
And they’re the only place I know of that sells arizona in 1 liter bottles which is way easier to pack home than a gallon from safeway.
this shouldn’t have made me laugh so hard but I almost cried
Love this thread.
When somebody says that “a man likes to feel like a man,” all I hear is “A man likes to feel superior to you and it’s your job to make him believe it.”
Someone said this to me once, that a man needs to feel like a man, I replied “well I’m not stopping him” and had to watch this fragile creature try to explain to me that my strong personality could demean men.
Like, if I have to pretend you are a strong man and cater to that then clearly you’re not that strong dude.
This post has the most weapons grade dick energy ive ever seen.
Never talk to me or my 42 trees again
it amuses me to see people being surprised/impressed/amused by this setup, because it’s extremely common on the plains. if you don’t plant a windbreak, your heating and cooling bills are huge, and storms do things like throw the lawnmower through the living room window, take the roof off, or cake the entire north side of the house with six inches of solid ice.
evergreens remain bendy even in the coldest weather, so – wait, no, not the coldest. i remember when i was a kid it got down to like -45 and the norway pines around my house were cracking like gunshots as the sap froze.
maples, incidentally, make that noise around -20f, and i hear it at least once every winter here in southern minnesota. but i only ever heard norway pines make it that one time.
so anyway that’s why we plant pine trees around our houses. because otherwise the wind would freaking kill us.
This is informative and perfectly sensible under the circumstances but I also cannot resist the temptation to compare it to planting stuff all around the boundary of your lot in The Sims
