Rabies is a viral infection that attacks the nervous system of warm-blooded men and animals. Once the symptoms of rabies develop, there is no successful treatment for it; only three patients in the medical history have survived the disease after its progression to this stage. It is very important to stop the disease from developing in people who may have been exposed to the rabies virus. To cause an infection, the rabies virus must enter the body and reach nerve cells. The virus can enter the body through broken skin. Droplets containing the virus can pass through mucous membranes in the eyes, nose, mouth or intestine. Usually, transmission occurs when rabid animals, with the virus in their saliva, bite people. The virus travel from the site of exposure to the brain through nerves. Once the virus establishes itself in the brain, it travels down and multiplies in different organs. Eventually, the virus reaches the salivary glands ant then, it releases itself into the mouth. The major risk of rabies comes from contact with the saliva, body fluids, or tissue of infected animals. Animals that can be infected with rabies include all mammals, but in particular: Wild animals--mostly foxes, skunks, bats, and raccoons Livestock--mostly cattle but occasionally horses, sheep, goats, and pigs Pets--mostly cats and dogs In Canada, rabies is also found in wolves, coyotes and other meat-eating animals. It is rarely found in rodents such as mice, squirrels, chipmunks, groundhogs, rabbits, rats, hamsters, or gerbils, so their bites do not usually pose a risk for rabies In people, rabies appears in several stages. Initially, a person who is bitten may notice unusual feeling or tingling around the wound. Soon afterwards, there is a period of tiredness, possibly with lack of appetite, headache, fever, cough, sore throat, abdominal pain, nausea, vomiting, and diarrhea. A period of extreme worry, irritability, inability to sleep, and depression follows, possibly with hallucinations. "Furious rabies" may follow with strange behaviors including biting other people. At this stage, victims have an uncontrollable fear of water. This is why rabies has been called "Hydrophobia." Sometimes "paralytic rabies" develops instead of furious rabies. With this form of the disease, the muscles gradually become paralyzed, starting from the site of the bite or scratch. A coma slowly develops that results to the death. In animals, rabies appears in two different forms. It may appear as furious rabies in which the animal changes behavior, becomes restless, wanders aimlessly, and bites any animal, person, or object in its way. Eventually the animal becomes paralyzed in the throat and hind legs, and dies. Or it may appear as "dumb rabies" in which an animal changes behavior becomes withdrawn or more affectionate, tries to hide, experience swallowing difficulty, and dies after a few days without ever becoming violent. All animals do not behave in the same manner when they have rabies. In medieval Europe, rabies was a deadly threat. In desperation, peasants turned to St. Hubert, the patron saint of rabies victims. Thousands of people would travel to Liege and pray that they would be spared. They also prayed for those already suffering. Peasants used iron bars or crosses called the "keys" of St. Hubert to protect themselves. Some would insert the keys into the walls of their houses. Others carried them with them to protect against the curse. Patients killed themselves or were killed when bitten by a dog believed to be rabid. Most peasants heated irons and applied them to wounds left by rabid animals. Surprisingly, if applied immediately, the wound would be sterilized. Of course, this was seen as a miracle. Even when scholars denounced these rituals, the peasantry believed in the keys until the late nineteenth century. Rabies has been a horrifying, tormenting and fatal disease for humans throughout history. It is feared still today. Nonetheless, rabies can be avoided, prevented and treated. Through education, we can correct the common misconceptions, raise public awareness and promote common sense when dealing with animals and the potential threat of rabies.