The nitty gritty on nails
Human fingernails serve to protect the distal phalanx from trauma and aid in picking up small objects
The basic anatomy of the human finger nail is broken into two major components:
nail unit: (a) nail fold, (b) nail matrix, (c) nail bed
horny end product of the nail matrix; 0.5 mm thick; covers fingertip like a watch glass
corneocytes are flattened, anuclear and devoid of organelles
Nail fold: angle between the nail plate and the dorsum of the digit skin is Lovibond’s angle.
Proximal nail fold is an extension of the dorsal skin of the digits as a fold lying superficial to the matrix; it is the site where abnormal capillary patterns can be directly visualized in certain disease states (SLE, systemic sclerosis).
Ventral epidermis of the proximal nail fold, also known as the eponychium, lies in direct contact with dorsal nail plate.
Cuticle is the extension of the horny layer of the eponychium onto the dorsum of the nail plate and serves to protect the structures at the base of the nail.
Nail matrix: melanocytes may be present, contributing to pigmentation of the nail plate.
Lunula is the most distal part of the matrix.
Nail bed: pink in color due to enriched vascular network.
Epidermis is very thin, horny layer scant, granular layer absent.
main chemical component consists of hard keratin which is high in sulphur compared to keratins of skin
high glycine-tyrosine rich matrix protein
18% water, lipid content <5%.
rigidity depends upon arrangement of cells, their adhesions and the orientation of the keratin fibres. It is independent of chemical composition or calcium content
Nail Growth and Development
nail growth is continuous throughout life
the longer the finger, the more rapid the growth
toenails grow at 33%-50% the rate of fingernails
regeneration of a fingernail after avulsion is 160 days; 40 days to emerge from the nail fold and another 120 days for growth to the fingertips
Interestingly enough, the composition of the nail bed varies by age and gender, “Results suggest that the Nitrogen/Sulfur ratio is indicative of sex differences and the Carbon/Nitrogen ratio of aging in healthy humans. Females have in their nails more sulfur. The increasing carbon content with ongoing age could be explained by loss of inorganic material from the nails, followed by a subsequent increase of organic material. The increasing C/N ratio gives evidence that keratin composition changes towards a higher amount of alpha-amino acids with aging.”
http://www.dermweb.com/hairnailsmucousmembranes/nails.htm
http://www.ncbi.nlm.nih.gov/pubmed/18424895
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http://chemwiki.ucdavis.edu/@api/deki/files/17454/cc8491ee4eb6938db43276ce3244a365.jpg
http://eliasandwilliams.com/wp-content/uploads/2013/01/epidermis-labelled-2-640.jpg