#acetyl-coa

[larryhbernsteinme]

Introduction to Metabolic Pathways

Introduction to Metabolic Pathways

Larry H. Bernstein, MD, FCAP, Writer, Curator, Editor

Chief Scientific Officer, Leaders in Pharmaceutical Intelligence

Introduction to Metabolic Pathways

http://pharmaceuticalintelligence.com/10/22/2014/larryhbern/ Introduction_to_Metabolic_Pathways

  Introduction to Metabolic Pathways

Humans, mammals, plants and animals, and eukaryotes and prokaryotes all share a common denominator in their…

View On WordPress

[healthwithtips]

Acetylcholine - Acetylcholine Synthesis, Release and Inactivation

Acetylcholine synthesis is catalyzed by the enzyme choline acetyltransferase In contrast to the multiple steps required to synthesize the catecholamine transmitters, ACh is formed in a single step from two precursors: choline and acetyl coenzyme A (acetyl CoA). The choline comes mainly from fat... Acetylcholine - Acetylcholine Synthesis, Release and Inactivation

[anidilynn]

Lipolysis and Beta Oxidation

English: Beta oxidation fatty acids Polski: Schemat beta-oksydacji kwasów tłuszczowych Zh-Cn：β-氧化…

View Post

[sportscasual]

the mnemonic on this lecture slide reads "a certificate in karma sutra should favour more orgasms" ok

[mrsmd-blog-blog]

Med School: Where Acetyl-CoA is our Friend

A lovely quote from our most recent e-book:

"The major pathway for catabolism of saturated fatty acids is called beta-oxidation, in which two-carbon units are successively removed from the carboxyl end of the fatty acid, in the form of our friend acetyl-CoA."

[destrucshann]

AP BIO: Chapter 9 - Krebs Cycle (my words)

Take the pyruvate from glycolysis

Pyruvate (2-carbon fragment) forms acetyl CoA 

Acetyle CoA enters Krebs and goes into the mitochondria

While pyruvate is making acetyl CoA, CO2 is formed and so is NADH

The 2-carbon acetyl CoA joins with a 4-carbon compound which makes a 6-carbon molecule; CoA carrier molecule released

From the 6-carbon molecule, CO2 is released which makes 6-carbon go to 5-carbon

During that step, hydrogen is released, which is given to NAD+ to make NADH(1)

5-carbon molecule releases CO2 again, releases hydrogen again (which is given to NAD+ to make NADH(2) again), but in this step, it makes ATP

Now we're left with a 4-carbon molecule

4-carbon molecule oxidizes, which releases hydrogens, and makes FAD2+ turn into FADH2, and also makes NAD+ turn into NADH(3)

FADH2 and NADH help regenerate the 4-carbon molecule that we started with, then the cycle repeats

So, 1 round of the Krebs Cycle makes 1 ATP, 3 NADH, 1 FADH2

Since there are 2 pyruvates, there will be 2 rounds of Krebs

Start: 2 pyruvates

End: 2 ATPs, 6 NADHs, and 2 FADH2s