#alecinix

[medsforcancer8]

Alecinix150mg(Alectinib)

Alecinix150mg(Alectinib) is a medication used for the treatment for non-small cell lung cancer. It works by blocking Anaplastic lymphoma kin

buy non small cell lung cancer medicine at an affordable price

[shifadrug]

Alecinix 150 mg (Alectinib)

Presentation Of Alecinix

Alecinix Each capsule contains Alectinib Hydrochloride INN equivalent to Alectinib 150 mg.

Description

Alecinix 150 mg (Alectinib) is a tyrosine kinase inhibitor that targets ALK and RET. In nonclinical studies, Alecinix (Alectinib) inhibited ALK phosphorylation and ALK-mediated activation of the downstream signaling proteins STAT3 and AKT and decreased tumor cell viability in multiple cell lines harboring ALK fusions, amplifications, or activating mutations. The major active metabolite of Alectinib, M4, showed similar in vitro potency and activity.

Alecinix (Alectinib) and M4 demonstrated in vitro and in vivo activity against multiple mutant forms of the ALK enzyme, including some mutations identified in NSCLC tumors in patients who have progressed on Crizotinib.

In mouse models implanted with tumors carrying ALK fusions, administration of Alecinix (Alectinib) resulted in antitumor activity and prolonged survival, including in mouse models implanted intracranially with ALK-driven tumor cell lines.