#oncology

[tiktoks-i-enjoyed]

[newsandstuffisee]

[unbfacts]

These are a patient’s own T cells, a type of white blood cell, taken out, genetically changed in a lab, and infused back in through an IV. The upgraded cells can spot a cancer target and attack it. This is T-cell immunotherapy, often called CAR T-cell therapy.

[odinsblog]

UnitedHealth Group is charging patients a markup for key life-saving drugs that could easily exceed their cost by a factor of ten or more, according to findings from the Federal Trade Commission.

The report, which levels the same allegations at CVS and Cigna, is the latest indictment of America’s broken healthcare system and comes on the heels of last month’s shocking murder of UnitedHealthcare CEO Brian Thompson.

The U.S. is notorious for incurring the highest costs per capita of any wealthy nation, yet failing to achieve an even remotely equivalent improvement in patient outcomes versus Europe’s social market-based economies.

Critics argue that is due largely to the highly opaque manner in which needless markups are hidden to conceal inefficiencies that serve various vested interests. These include, but are not limited to, the big three drug middlemen known as pharmacy benefit managers (PBMs).

According to the FTC report, UnitedHealth’s OptumRx, along with Cigna’s Express Scripts and CVS Caremark Rx, were able to collectively pocket $7.3 billion in added revenue above cost during the five year period of the study through 2022.

“The Big 3 PBMs marked up numerous specialty generic drugs dispensed at their affiliated pharmacies by thousands of percent, and many others by hundreds of percent,” it concluded.

A thousand percent increase in the price of a drug that costs $10 wholesale would result in a retail price of $110.

This markup rate applied to 22% of the specialty therapies examined, including Imatinib, a generic used to treat leukemia, or non-oncological Tadalafil for pulmonary hypertension. Others such as Lamivudine needed by HIV-positive patients were nearly quadruple the price of their acquisition cost.

Independent Vermont Sen. Bernie Sanders has been conducting Congressional hearings in an attempt to shed light on the problems posed by these drug middlemen as well as drugmakers themselves.

(continue reading)

[theoddvet]

Happy spooky month ft a neoplastic cell who decided it needed to grow cytoplasmic tentacles in order to produce the glob of Mystery Pink Stuff instead of just hugging it like a normal cell

[empathwitchliv]

Sickle Cell Warrior on chemotherapy for 22 years ✨️

[reasonsforhope]

I'm worried about the rising rate of young adults getting cancer.

For what it's worth, we've actually made a shocking amount of progress against cancer - especially the most common cancers like breast cancer, and especially in the past 30 years.

Cancer rates have been falling, often dramatically (x, x, x, x, x, x). One of the best examples it that breast cancer deaths in the United States dropped 58% between 1975 and 2019 (x).

Right now, we're at the beginning of an absolute revolution in cancer care that promises to increase survival rates even further. This revolution has been going on to a lesser degree since the first human genome was successfully sequenced in the early 2000s (and in fact, the first gapless sequencing of a human genome was finally finished just two years ago, in 2022), and to a greater extent since CRISPR DNA-editing technology was first successfully tested in 2013, and since medical digitzation/digital communication and vaccination were massively spurred ahead in 2020, by the COVID pandemic (x, x).

Right now, the results of this revolution are only beginning to trickle out into actual treatments. But I guarantee you, in the next one to three decades, the way we fight cancer will be massively transformed.

We're talking personalized genome sequencing for each person with cancer - not just for early and better detection, but even to figure out what types of treatments will work best. (x, x, x, x)

We're talking using CRISPR-based DNA editing to literally cut cancer-causing mutations out of your DNA, to edit the genes of immune cells to better detect and kill cancer cells, and to kill cancer-causing viruses. (x, x, x, x)

We're talking using CRISPR-based screening to figure out how chemotherapy resistance works, so that we can overcome it - and even weaponize it. (x, x)

We're talking using CRISPR to edit immune cells so that they recognize and target the mutations of a single individual's specific tumor. (x)

We're talking new types of testing that can predict if cancer will return years before it shows up on scans. (x)

We're talking using (non-generative) AI to massively increase the accuracy and earliness of cancer detection - which by the way is already starting to happen, there are several AI-based systems that detect cancer earlier and more accurately than doctors do. (x, x, x, x, x, x)

Also, the more we transition to a green, sustainable, and ethical future, the fewer cancer-causing substances will be in the environment (fossil fuels, oil drilling, and mining are massive sources of carcinogens at every point in the process).

Cancer is awful. That is a massive understatement. But the fight against cancer is one where there are so many reasons for hope.