#anthracyclines

[arcjournals-blog1]

Ventricular Repolarization Intervals in Children Previously Treated with Anthracyclines

Read More : http://dx.doi.org/10.20431/2455-5991.0302002 ARC Journal of Cardiology Read More About Journal : https://www.arcjournals.org/journal-of-cardiology/

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xaize - lol so after going through all the cancer meds, memorizing all the other meds for hypertension, cholesterol, diabetes, and etc. seems like a walk in the park

Anthracyclines - not cell phase specific since they just mix into DNA and inhibit topoisomerase II while making oxygen radicals whenever and wherever they fucking want to...chemotherapy - just hit it hard and fast

Black box warnings 

1: heart toxicity (that’s why we got lifetime doses, so we don’t die of fucking heart failure along with the cancer)

2: secondary malignancy (you’re fucking messing with DNA, which makes a second type of cancer possible)

3: severe myelosuppresion in hepatic dysfunction (uh any cancer drug except for 2 - bleomycin and vincristine!)

4: vesicant (yeah these are pretty toxic) - get them cold compresses and dexrazoxane (Totect) or DMSO 

Contraindications - so if the above are the BBW, I wonder what the fuck will be the CIs....

1: HF/MI/arrhythmias - cus if you already got a bad heart, why the fuck would you take this if it’s gonna mess it up more

2: bone marrow suppression - ANC <1500 (make sure you can calculate this shit); well if you have a shitty immune system, you might die from an infection before the cancer

3: previous usage of anthracyclines - we have fucking lifetime doses, we sure as hell ain’t gonna use it again

4: severe liver impairment - well if you’re immune system’s more likely to be shitty with liver issues, then no don’t take this drug

Side effects - well if that was the CIs, then what would the SX be I wonder?

Myelosuppresion - how many times will this be mentioned? fucking >9000

Alopecia - most cancer drug...hallmark side effect

N/V - most cancer drugs...hallmark side effect

Mucositis - most cancer drugs

Injection site extravasation - well duh..it’s a potential event

Hepatitis

Red urine and body secretions - no it’s not blood, so don’t freak out!

Individual drugs

Doxorubicin (Adriamycin conventional not equal to liposomal Doxil)

450-550mg/m2 lifetime dose

>60mg/m2 - high emetic risk = 3 drug N/V treatment

>250mg/m2 cumulative - might want to start keeping an eye on your heart before and during

>300mg/m2 cumulative - getting close to the end; add some Zinecard (dexrazoxane for heart protection not for vesicant treatment)

Idarubicin (Idamycin)

120-150mg/m2 lifetime

Daunorubicin (Cerubidine conventional not equal to liposomal DaunoXome)

>320mg/m2 - might want to start keeping an eye on your heart before and during

400-550mg/m2 lifetime dose

Mitoxantrone (Novantrone) - hey structurally different, but works the same; it’s the odd one out, so it’s sad and makes ya blue (blue body fluids instead of red)

140mg/m2 lifetime dose