L. BACCAGLINI1, D. THERIAQUE2, R. LALLA3, G. SERRANO1, D. PETERSON3, and J. SHUSTER4, 1College of Dentistry, University of Florida, Gainesville, FL, 2Shands Clinical Research Unit, Clinical and Translational Science Institute, University of Florida, Gainesville, FL, 3School of Dental Medicine, University of Connecticut Health Center, Farmington, CT, 4College of Medicine, University of Florida, Gainesville, FL
Objectives: Recurrent aphthous stomatits (RAS) is a painful condition affecting over 100 million US individuals at some point in life. RAS occurs more frequently during growth, although the reason for this age distribution is unknown. Peak growth velocity is also the most critical period for progression of scoliosis, a disease that is more prevalent in those demographic subgroups most affected by RAS. Thus, we determined whether there is an association between scoliosis and aphthous/intraoral ulcers (RAS/IOU). Methods: We conducted data management and statistical analyses of the National Health and Nutrition Examination Survey (NHANES III) using SAS 9.1 and SUDAAN 9.0.1 to account for the complex multistage stratified sampling design with oversampling of certain population subgroups. The target population was the civilian non-institutionalized US population aged 20+ years. The sample consisted of 18,710 individuals. The outcome was a history of canker sores or other intraoral ulcers in the past 12 months (yes/no). The main exposure was a history of medically diagnosed scoliosis (yes/no). We calculated crude and adjusted odds ratios (OR) and 95% CI of having a positive RAS/IOU history comparing individuals with or without a history of scoliosis using the CROSSTAB and RLOGIST procedures. Results: A total of 2,056 participants had a history of RAS/IOU. Individuals with scoliosis (n=420) had higher odds of having had a history of aphthous/intraoral ulcers in the past 12 months compared to those with no history of scoliosis (crude OR=1.83; 95% CI =1.33-2.51). The association persisted after adjustment for demographic factors (OR=1.38; 95% CI=1.00-1.89). Conclusions: A possible explanation for the association between RAS/IOU and scoliosis is that the two conditions may share in part similar risk factors during puberty, such as factors related to musculoskeletal and mucocutaneous growth and repair.
Funding: This research was supported in part by NIH grants #R03DE016356, M01RR00082, U54RR025208 and R21DE018714.