Stem cells and organoids offer a new understanding of APOL1 kidney disease
Chronic kidney disease (CKD) affects more than 700 million people worldwide and is caused by genetic and environmental factors, as well as existing medical conditions. Known genetic risk factors for CKD include mutations in a gene called APOL1. These are rare in most populations, but two risk variants are present in as much as 13 percent of people of West African origin, and another 38% possess…
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