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"In a new study, researchers made the skin on the skulls and abdomens of live mice transparent by applying to the areas a mixture of water and a common yellow food coloring called tartrazine. Living skin is a scattering medium. Like fog, it scatters light, which is why it cannot be seen through. "We combined the yellow dye, which is a molecule that absorbs most light, especially blue and ultraviolet light, with skin, which is a scattering medium. Individually, these two things block most light from getting through them. "But when we put them together, we were able to achieve transparency of the mouse skin," said Ou, who, with colleagues, conducted the study while he was a postdoctoral researcher at Stanford University before joining the UT Dallas faculty in the School of Natural Sciences and Mathematics in August. The "magic" happens because dissolving the light-absorbing molecules in water changes the solution's refractive index—a measure of the way a substance bends light—in a way that matches the refractive index of tissue components like lipids. In essence, the dye molecules reduce the degree to which light scatters in the skin tissue, like dissipating a fog bank. In their experiments with mice, the researchers rubbed the water and dye solution onto the skin of the animals' skulls and abdomens. Once the dye had completely diffused into the skin, the skin became transparent. The process is reversible by washing off any remaining dye. The dye that has diffused into the skin is metabolized and excreted through urine. "It takes a few minutes for the transparency to appear," Ou said. "It's similar to the way a facial cream or mask works: The time needed depends on how fast the molecules diffuse into the skin." Through the transparent skin of the skull, researchers directly observed blood vessels on the surface of the brain. In the abdomen, they observed internal organs and peristalsis, the muscle contractions that move contents through the digestive tract. The researchers have not yet tested the process on humans, whose skin is about 10 times thicker than a mouse's. At this time it is not clear what dosage of the dye or delivery method would be necessary to penetrate the entire thickness, Ou said. "In human medicine, we currently have ultrasound to look deeper inside the living body," Ou said. "Many medical diagnosis platforms are very expensive and inaccessible to a broad audience, but platforms based on our tech should not be." Ou said one of the first applications of the technique will likely be to improve existing research methods in optical imaging."

source: https://medicalxpress.com/news/2024-09-yellow-dye-solution-tissue-transparent.html

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Role of MLOps in Biomedical Research

Biomedical Research with its cutting edge innovations and futuristic outlook can positively utilize MLOps for successful drug discovery. In sync with current times, research in this field is proactively driven by a need to offer timely and qualitative healthcare solutions.

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