From • @pathnuggets Cytoplasmic vacuolization of myeloid and erythroid precursors in bone marrow. Commonly seen in copper deficiency. Copper deficiency can be confused with MDS because patients typically present with pancytopenia. Can also see dysplasia in copper deficiency (why it should be ruled out when working up for MDS). Since copper is mostly absorbed in the stomach and proximal duodenum, think about possible copper deficiency in patients who have undergone GI surgery such as gastrectomy. TPN and Zinc supplements can also cause copper deficiency. Zinc and copper compete for absorption in GI track and zinc usually wins. (Be careful and don’t take too many zinc supplements) #pathnuggets #pathology #pathologyeducation #pathologynuggets #bonemarrowpathology https://www.instagram.com/p/CjUfM7LDnOD4fYBZxDaj5IjxWFp0on8qI9RmiY0/?igshid=NGJjMDIxMWI=