The Function Of Hydrolysed Proteins
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Biotech & Biochem Research Items
Bioactive Healthy Protein As Well As Peptides Market Gamers, Dimension, Cagr, Applications, Kinds, Analysis, Fads, Forecast To 2027.
Cardarine Gw.
Unquenched Calibration Peptide For Snaptide ® 521. Vamptide ® Peptide Substrate (o.
Typical applications for these identified peptides consist of the Fluorescence (or Förster) Resonance Power Transfer analysis of receptor-ligand interactions, protein-protein interactions and also the cleavage of substratum molecules. An unique antifungal bicyclic peptide from the aquatic sponge Theonella generates development of vacuoles and overflow of 1, 3-beta-D-glucan. Theonellamide F inhibits development of numerous pathogenic fungi and has cytotoxic properties versus L1210 as well as P388 leukaemia cells. It can be utilized as essential biomarker for the measurement of antigens and also as a non-invasive method for discovering intrusive fungal infections. These can triggering injury and illness when touching body cells, as they engage with biomolecules such as enzymes, hormones and mobile receptors. Toxins vary substantially in their extent, ranging from normally minor or acute responses to fatality. There are several ways to generate powerful bicyclic peptides, one of the most usual being phage-encoded libraries.
In expert facilities, utilizing B-type natriuretic peptide blood degrees to guide treatment in people with persistent heart failure shows pledge however did not improve survival for all groups. In this review, the advantage was just seen in patients aged much less than 75, who made it through an added 1.5 years on average, and potentially those with bad heart feature.
Biotech & Biochem Research Study Items
Using this procedure a single linear peptide substratum will certainly yield a distinct collection of customized cyclic peptides (5 in the instance shown in Fig. 2), each with a distinct conformation, and a variety of target binding and also physicochemical residential or commercial properties. In all present-day microorganisms, details inscribed in DNA, the hereditary material of the cell, is converted via an RNA intermediate right into proteins, the molecular makers of the cell. Nevertheless, proof recommends that in a remote transformative previous our single-celled forefathers made use of just RNA for both genetic info storage space and metabolism. A foundation of this "RNA world" would certainly have been an RNA able to replicate itself.
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Dispute Over Muscle-Building Drugs Goes to Court.
Posted: Thu, 12 Oct 2017 07:00:00 GMT [source]
The Swiss based Bachem Team is a public, innovation-driven company concentrating on the development and also manufacturing of pepTides and oligonucleoTides. As a complete supplier Bachem uses items for clinical growth and business applications along with a thorough directory as well as unique custom synthesis.
Bioactive Healthy Protein As Well As Peptides Market Players, Dimension, Cagr, Applications, Kinds, Analysis, Trends, Forecast To 2027.
Now-a-days, it is obtaining changed with solid-phase synthesis due to its simplicity as contrasted to the former. However, fluid stage synthesis remains valuable in the large production of peptides for commercial objectives. To seek a peptide mimetic, it is very vital to determine a peptide or a peptide sequence within the target protein that is taken into consideration for the assay. Structural restrictions are considered to seek the legitimacy of the functions.
Bicycles can be conveniently determined to drug a vast range of targets and target classes, including lots of that have actually until now been undruggable with little particles, such as protein-protein interactions. This screening procedure self-selects for Bicycles that are amenable to add-on-- frequently described as conjugation-- to other molecular hauls such as cytotoxins, natural immune activators or other Bikes. Bikes can be connected with each other with artificial ease to produce complex molecules with combinatorial pharmacology. Alternatively, Bikes in the form of multimers can additionally be used as standalone therapeutics, including those that we are discovering in our T-cell modulator program. Our team believe that the versatility of our Bicycles as well as our effective testing platform allow brand-new therapies to be quickly developed and also lowered to exercise to potentially serve varied restorative applications throughout a variety of indicators.
Cardarine Gw.
Bicyclic peptides such as the amatoxins and phalloidin contain a connecting team, typically in between two of the side chains. There are a variety of cyclic peptide hormones that are cyclised through a disulfide bond between two cysteines-- for instance, somatostatin as well as oxytocin.
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MK-677 treatment reduced serum total testosterone (P
Rosario is an Elderly Scientist at the Medicinal Chemistry Institute (IQM-CSIC), Madrid. She is associated with peptides, additional framework mimics as well as small-molecule peptidomimetics of application in biological/medicinal chemistry programs, especially pertaining to the modulation of ion networks and associated proteins. The initial professional tests of Modi-1, the lead candidate from the Moditiope ® system, are anticipated to target people with triple unfavorable bust cancer cells, ovarian cancer cells as well as osteosarcoma. To utilize the wide applicability of Bicycles, we have actually participated in several collaborations beyond our inner focus in oncology. These calculated collaborations, each with partners that have deep restorative know-how, are based upon the wide applicability of the proprietary Bike platform and its capacity to deal with a wide variety of targets. These partnerships improve our ability to bring this crucial class of medicines to clients with devastating conditions besides cancer.
Unquenched Calibration Peptide For Snaptide ® 521. Vamptide ® Peptide Substratum (o.
Phage approaches have been established for illness targets as well as the generation of powerful phage complied with by cyclisation of the phage-encoded linear peptides including three cysteine residues. The method was efficiently used on human plasma kallikrein inhibitors generated with nanomolar affinities. Depsipeptides are peptides in which one of the amide linkages is replaced by a lactone link. Some cyclic as well as bicyclic depsipeptides are cyclised between the C-terminal carboxyl as well as the side chain of a threonine or serine deposit.
In studies of trained as well as untrained mice, Cardarine triggered fast twitch muscular tissue fiber to convert to slow down jerk muscular tissue fibers.
Where Cardarine or GW50515 becomes very fascinating is that PPARD activation raised mitochondrial biogenesis in the muscular tissue, which can renovate your muscle cells!
At simply 1mg per day for 3 weeks a professional trial showed an average gain of 1.21 kg in LBM which is virtually 1 extra pound of LBM weekly which is definitely crazy thinking about the time frame as well as the reality that they were not even training.
Because of this Cardarine is typically called a workout mimetic as only workout could normally make these adjustments to your metabolic rate and also fiber composition.
The typical results from this are 7-10lbs of LBM, good increases in strength and little to lean loss.
The typical dose for performance enhancement is 2-10mg daily for 4-8 weeks.
The survival of these markers in historical bones was examined using a collection of 26 ovicaprid specimens from Domuztepe, a Neolithic site in south main Turkey. These pens were used to examine the osteological decision of 24 of the Domuztepe bones, and determine the varieties for 2 immature specimens. The collagen-peptide technique has advantages over other non-morphological approaches of sheep/goat difference because of the long-term survival of collagen over other biomolecules such as ancient DNA. The outcomes additionally highlighted the problems in trusting one morphological standard, in this instance on the distal span, to compare lamb and goat bones.
Our screening platform can be released to evaluate either soluble healthy proteins or cell-based targets. Along with being resource-efficient and also rapid, the process distinctly utilizes an essential on-phage binding assay that notifies structure activity connections. We can include a broad series of tiny particle scaffolds into Bicycles to raise diversity as well as provide differentiated physicochemical as well as structural buildings. , Methods to improve plasma fifty percent life time of peptide and also healthy protein medicines, Amino Acids, 2006, 30, 351-- 367 CrossRef CAS PubMed. , Testimonial cyclic peptides on a merry-go-round; towards medicine style, Biopolymers, 2015, 104, 453-- 461 CrossRef CAS PubMed. , Impact of cumbersome side chains of amino acids on the option conformation of peptide fragment (81-92) derivatives of CD4, TYICEVEDQKEE, as researched by NMR spectroscopy as well as molecular modeling, Biochim. , Constraining cyclic peptides to simulate protein framework motifs, Angew.
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" width="309px" alt="Sarms advantages"/>
Nonetheless, there was a reduction in hospital admissions for heart failure for everyone. information BPC157 Poland got his PhD in Immunology at the University of Tuebingen. He has actually established the modern technology system XPRESIDENT, which incorporates techniques from peptidomics, genomics and immunology in order to discover unique and also naturally presented cancer antigens. The system is commercialised by immatics biotechnologies, where Toni Weinschenk, likewise a founder of the company, is heading the drug discovery team. Using a hydrolysed protein can assist to decrease GI and/or skin-related indications as the hydrolysed healthy protein is unable to crosslink receptors on pole cells, as a result minimising degranulation as well as launch of histamine. Bradykinin is an inflammatory mediator and an important regulator of blood pressure, kidney feature as well as heart feature, as well as likewise involved in swelling.
By modifying the amino acid sequence we can regulate whether these peptides set up into hydrogels composed of nanofibers or peptide nanotube structures. We have developed our own internal modern technology to allow for the post-folding labelling of little healthy proteins. This approach, which uses a masked cysteine moiety, can be used to present a fluorophore or PEG particle bearing maleimide performance right into the product after the disulfide bridges have been developed. This technique has actually been applied to a variety of chemokine, enhance protein as well as conotoxin targets. Almac has considerable experience in the conjugation of peptides to a series of provider healthy proteins including keyhole limpet hemocyanin, Ovalbumin, Bovine Product Albumin, and also Human Lotion Albumin. Peptides are an expanding class of medicines, with buildings in between little particles as well as biologics. Insulin is a widely-used example of an establised peptide-based therapy.
With 50 years of experience as well as subsidiaries in Switzerland, the United States, the UK and Japan, Bachem is the companion of selection for the biotech and also pharma sector worldwide. Over 20+ studies have actually been released making use of the RALA system, varying from the basic style as well as application of an effective cell permeating peptide to use as a possible healing mRNA injection candidate. Variations around a hit particle can be made by utilizing various enzymes and also reaction plans, including more tailoring by oxidation of the heterocycles and also decor with prenyl teams.
The development of such a RNA replicase is commonly considered to mark the bottom line in the beginning of life. Research from Philipp Holliger's group in the LMB's PNAC Department has actually dropped new light on exactly how the RNA globe, and also its RNA replicase, might have first come to be dependent on short proteins, beginning the change to our modern biology. This latest paper discusses exactly how hydrolysed salmon peptides could change glycerine-- a nutritionally empty active ingredient-- in semi-moist pet snacks delivering high dietary protein value and also great palatability, along with other wellness benefits.
Ultimately, the authors of this publication hope to generate a spark of gratitude for the possible and also appeal of cyclic peptides, contrasting the rather slandering undertone reverberating along with their original word stem peptós. Head-to-tail-, side chain-to-side chain-, as well as side chain-to-terminus-cyclization.34,35 Several loops are also frequently discovered in peptides, e.g. a combination of a head-to-tail- as well as a side chain-to-side chain-macrocycle. Thus the most basic homodetic macrocyclic peptide is a covalent circuit built up of at the very least 4 deposits. However, smaller (non-macro-) cyclic concepts also occur having only a restricted number of constrained bonds. Figure 1.3 illustrates several of the most basic and also common motifs.34 Contrasting these structures, it promptly becomes clear that each specific setting of cyclization can result in a completely various geometry of the bent substance. Liquid-phase synthesis is a standard strategy for the synthesis of peptides.
N2 - We explain a method of isolating as well as assessing a solitary collagen peptide able to compare lamb as well as goat bone collagen. Microflow can assist in level of sensitivity gains for a wide array of analytes, yet the best advantage has been for peptides and healthy proteins. A DPhil pupil is called for to check out the technology further to seek opportunities to improve antigen discussion in both antigen presenting cells as well as target cells. This will be done via establishing one or two prospects of vaccines to preclinical phase. Bachem has confirmed efficacy of Trend Fluor fluorescent color in a a Förster Vibration Power Transfer evaluation of uptake of Amyloid β-Protein (1-42) by J774 macrophages, gotten from BALB/c computer mice. The Amyloid β-Protein (1-42) was labeled with Trend Fluor ™ 5WS fluorescent dye to enable visualization. The cells were presented in bright area imaging overlaid with the eco-friendly fluorescent network of the peptides.
Low bioavailability of the peptides is also a significant downside connected with peptide medications which is partly because of the inadequate membrane layer transportation ability of its amide backbone structure. • the first effective randomised professional tests in cancer clients that might lead to the very first FDA registration of a healing cancer cells vaccination within the following few years. pIII small coat healthy protein which shows a cell targeting ligand (e.g. RGD4C), which allows extremely targeted distribution to the target cell, for instance a tumour cell. Abdominal Muscle - We explain a technique of isolating and also evaluating a solitary collagen peptide able to distinguish between lamb and goat bone collagen. The 33 amino acid peptide from both sheep and also goat collagen was sequenced as well as shown to differ between both species at two settings. Evaluation of a variety of caprines showed that the series adjustments took place between the aberration of the Himalayan tahr as well as the ibex which the suggested goat marker is analysis of all Capra species and types.
