#c diff research

[cdifffoundation]

Clostridioides diffiicle Thrives In an Inflammed Environement ....Research Study From North Carolina State University

Clostridioides diffiicle Thrives In an Inflammed Environement ….Research Study From North Carolina State University

Clostridioides difficile thrives in an inflamed environment by generating toxins that support prolonged infection, according to a study from North Carolina State University. The study, published in Nature Communications, showed how C. diff produces toxins that cause inflammation, eliminating competing bacteria and releasing peptides and amino acids that support the growth of C. diff. “C. diff…

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[cdifffoundation]

CspC Plays a Critical Role in Regulating C. diff. Spore Germination in Response to Multiple Environmental Signals.

CspC Plays a Critical Role in Regulating C. diff. Spore Germination in Response to Multiple Environmental Signals.

Abstract

The gastrointestinal pathogen, Clostridioides difficile, initiates infection when its metabolically dormant spore form germinates in the mammalian gut. While most spore-forming bacteria use transmembrane germinant receptors to sense nutrient germinants, C. difficileis thought to use the soluble pseudoprotease, CspC, to detect bile acid germinants. To gain insight into CspC’s unique…

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[cdifffoundation]

Researchers Find Sulfated glycosaminoglycans and Low-Density Lipoprotein Receptor Contribute To Clostridioides difficile Toxin A Cell Entry

Researchers Find Sulfated glycosaminoglycans and Low-Density Lipoprotein Receptor Contribute To Clostridioides difficile Toxin A Cell Entry

  Abstract

Clostridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic epithelium during C. difficile infection. TcdA contains a carbohydrate-binding combined repetitive oligopeptides (CROPs) domain that mediates its attachment to cell surfaces, but recent data suggest the existence of CROPs-independent receptors. Here, we carried out genome-wide…

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[cdifffoundation]

A Systematic Review Evaluates the Diagnostic Accuracy of Laboratory Testing Algorithms that Include Nucleic Acid Amplification Tests (NAATs) to Detect the Presence of C. difficile

A Systematic Review Evaluates the Diagnostic Accuracy of Laboratory Testing Algorithms that Include Nucleic Acid Amplification Tests (NAATs) to Detect the Presence of C. difficile

SUMMARY

The evidence base for the optimal laboratory diagnosis of Clostridioides (Clostridium) difficile in adults is currently unresolved due to the uncertain performance characteristics and various combinations of tests.

This systematic review evaluates the diagnostic accuracy of laboratory testing algorithms that include nucleic acid amplification tests (NAATs) to detect the presence of…

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[cdifffoundation]

Dr. Michael Pride, a Pfizer Scientist, Leads a Team Searching For Ways to Improve Diagnosis, Prevention and Treatment of Clostridium difficile Infections

Dr. Michael Pride, a Pfizer Scientist, Leads a Team Searching For Ways to Improve Diagnosis, Prevention and Treatment of Clostridium difficile Infections

Dr. Pride of Pfizer leads a team that is searching for ways to improve diagnoses & treatment of C. difficile, Dr. Michael Pride is the Executive Director, Vaccine Research and Development at Pfizer

Challenges, Chance and Looking Forward. Historically, a difficult diagnosis process has posed challenges to treatment for C. difficile infections, as detection is not straightforward. Dr. Pride…

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[cdifffoundation]

Gut Microbiome Research High-resolution Profiling Reveals the Extent of Clostridium difficile (C.diff.) Burden

Microbiome profiling through 16S rRNA gene sequencing has proven to be a valuable tool to characterize the diversity and composition of gut microbial communities, including in studies of CDI development and recurrence.8

  Authors:

Ninalynn Daquigan,

Anna Maria Seekatz,

K. Leigh Greathouse,

Vincent B. Young &

James Robert White

npj Biofilms and Microbiomesvolume 3, Article number: 35 (2017)

doi

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[cdifffoundation]

C.difficile Study Using C. difficile Conditioned Medium of Six Different C. difficile Strains

        Horvat S1, Mahnic A2, Breskvar M3,4, Dzeroski S3,4,5, Rupnik M6,7. Abstract

Clostridium difficile infection (CDI) is typically associated with disturbed gut microbiota and changes related to decreased colonization resistance against C. difficile are well described.

However, nothing is known about possible effects of C. difficile on gut microbiota restoration during or after CDI.

In this…

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[cdifffoundation]

Researchers Suggest a Portion Of C. diff. Cases In Europe Involve Infections Associated With Other Sources Outside of Healthcare-Associated Infections

As part of a multicenter study, investigators from the University of Oxford, the University of Leeds, Astellas Pharma Europe, and elsewhere used a combination of ribotyping, sequencing, phylogenetics, and geographic analyses to retrace the genetic diversity and potential sources of C. difficile isolates involved in infections in European hospitals.

Recent research suggests a proportion of…

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