#cardiotoxicity

[cancer-researcher]

[cancer-researcher]

[oaresearchpaper]

Cancer ranks second in frequency among non-communicable diseases after cardiovascular disorders. The increased life expectancy has made cancers more common, making it crucial to avoid side effects of the medications used to treat them. SGLT2i medications lower the risk of significant cardiovascular events and heart failure-related hospitalizations, as shown in clinical trials. Dapagliflozin is one such medication that is primarily regulated by blood glucose levels but may also impact cardiac disorders through other processes. This study will evaluate the potential protective effects of Dapagliflozin on DOX-induced cardiotoxicity in female rats, manifested by changes in biochemical parameters in tissue and serum samples, histopathological differences, and compare their changes. Twenty-four rats were divided into three weight-based groups. The first group received saline, the second group received doxorubicin, and the third group received dapagliflozin for three days before receiving doxorubicin for two weeks. Doxorubicin causes cardiotoxicity, as evidenced by increased caspase-3 and inflammatory markers. Dapagliflozin reduces cardiotoxicity by increasing SOD and GSH and decreasing caspase 3, as well as improving the CMYO score and lesions. Dapagliflozin successfully mitigated DOX-induced cardiotoxicity in rats at the concentrations utilized in this investigation. This phenomenon potentially pertains to inhibiting and safeguarding against oxidative stress, the pathway of apoptosis, and the inflammatory response.

[safetymedicines]

[publicationgenesis]

Recent research article published entiled “Treatment Of Albino Rats With Oltipraz (4-MethyL-5-PyrazinyL-3H-1,2-Dithiole-3-Thione Protects Against Doxorubicin-Induced Cardiotoxicity”

https://www.genesispub.org/treatment-of-albino-rats-with-oltipraz-4-MethyL-5-PyrazinyL-3H-1-2-Dithiole-3-Thione-protects-against-doxorubicin-Induced-cardiotoxicity

[jppres]

Protective effect of propolis from Tigzirt on epirubicin-induced cardiotoxicity and nephrotoxicity

Protective effect of propolis from Tigzirt on epirubicin-induced cardiotoxicity and nephrotoxicity

Image: Wikimedia Article published in the Journal of Pharmacy & Pharmacognosy Research 9(4): 549-562, 2021. Original article Sara Chaa1, Mokhtaria Yasmina Boufadi1,2*, Soumia Keddari1, Amina Hayat Benchaib3 1Faculty of Natural Sciences and Life, Université de Abdelhamid Ibn Badis, Mostaganem, Algeria. 2Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, Université Libre de…

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