#cefotaxime

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Cefotaxime

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Cefotaxime Drug

Medical information for Cefotaxime on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Renal Dose, Hepatic Dose.

[ijtsrd]

Determination of Stability Constants and Gibbs Free Energies of Cefotaxime Zn II Complex at Different Temperatures

by O. V. Ikpeazu | I. E. Otuokere | K. K. Igwe "Determination of Stability Constants and Gibbs Free Energies of Cefotaxime-Zn(II) Complex at Different Temperatures"

Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020,

URL: https://www.ijtsrd.com/papers/ijtsrd31797.pdf

Paper Url :https://www.ijtsrd.com/chemistry/other/31797/determination-of-stability-constants-and-gibbs-free-energies-of-cefotaximeznii-complex-at-different-temperatures/o-v-ikpeazu

callforpaperarts, artsjournal, peerreviewedjournal

Cefotaxime is a synthetic lactam antibiotic that is active against Gram negative and Gram positive bacteria. Cefotaxime is able to chelate metal ions due to the presence of C=O, NH2, COOH, COOR, NH and NO electron donating groups. The stability constants and Gibbs free energies of cefotaxime Zn II were determined colorimetrically at 25 and 40 oC using continuous variation and mole ratio methods. The formation of Zn II complex with cefotaxime was studied colorimetrically at an absorption maximum of 430 nm at different temperatures. The data showed that Zn II and cefotaxime combine in the molar ratio of 1 2 at pH 7.4 with ionic strength maintained using 0.1M KNO3. Calculated stability constants values were 1.96 x 105 and 1.28 x 105 using continuous variation method and 1.11 x 105 and 1.11 x 105 using mole ratio methods at 25 and 40 oC respectively. Calculated GO for the complex were 3.01 x 104 and 3.06 x 104 J using continuous variation method and 2.88 x 104 J and 3.02 x 104 J using mole ratio method at 25 and 40 oC respectively. The stability constant results suggested that cefotaxime used in the study is a good chelating agent and can be an efficient antidote in the therapy of Zn II overload or poisoning. 

[almazydcom]

وعن #سيفوتاكس حديثنا، وهو من المادة الفعالة #سيفوتاكسيم #Cefotaxime ولذا فإن #Cefotax هو مضاد حيوي واسع المجال. طالع معلومات أكثر عنه عبر #المزيد

(via سيفوتاكس – Cefotax | مضاد حيوي واسع المجال | المزيد)

[preventivehealthcare101-blog]

Cefotaxime | Find why Cefotaxime is prescribed including its typical usage, side effects and safety, interactions, warnings and ask a doctor for expert advise on Cefotaxime at MediKlik.com

Cefotaxime | Find why Cefotaxime is prescribed including its typical usage, side effects and safety, interactions, warnings and ask a doctor for expert advise on Cefotaxime at MediKlik.com