Jun 10, 2013
Chromophobe Renal Cell Carcinoma "ChRCC"
Hi there, few days ago i stumbled upon this relatively uncommon renal tumor and misdiagnosed it as Conventional renal cell carcinoma on smears. " seams i got so much to learn "
So lets review the Cytological Characteristics of this tumor :
polygonal cells.
well defined borders.
granular to light transparent cytoplasm, clear cells are rare.
accentuation of the granularity at the periphery of the cell.
central halo giving the cell koilocyte like appearance.
the nuclei are eccentric with anisonucleosis.
some of the nuclei are condensed with raisinoid appearance.
Beware of the Eosinophilic Variant of Chromophobe RCC as it very hard to differentiate from Renal Oncocytoma which is a benign tumor.