Feb 8
Integrative cross-tissue and spatially resolved single-cell profiling uncovers tumour-educated inflammatory remodelling of tissue-resident macrophage ecosystem with immunotherapeutic prognostic significance in pan-cancer - Research
Background: Tissue-resident macrophages (TRMs) exhibit dual roles in tumor progression, yet their functional reprogramming within the tumor microenvironment (TME) remains a critical unresolved question. Methods: We integrated single-cell and spatial transcriptomics from a pan-cancer atlas of 1.39 million cells across five malignancies with 2,318 bulk RNA-seq samples to investigate macrophage…
#crosstissue#doi:10.1002/ctm2.70608#ecosystem#humans#immunotherapeutic#Immunotherapy / methods#Inflammation#inflammatory#Integrative#Jianhua Yin#Macrophage#Macrophages* / immunology#MEDLINE#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#Neoplasms* / genetics#Neoplasms* / immunology#Neoplasms* / therapy#NIH#NLM#PanCancer#pmid:41655028#profiling#Prognosis#prognostic#PubMed Abstract#remodelling#research