Radiotherapy synergizes with CD24 blockade to initiate macrophage-driven systemic antitumor immunity in non-small cell lung cancer - Research
Background: Radiotherapy (RT) has been shown to elicit antitumor immune responses, yet it rarely induces durable systemic immunity. The identification of immune checkpoints that constrain RT-induced immune activation remains an unmet clinical need. Methods: Using genetic deletion, pharmacologic blockade, syngeneic bilateral and orthotopic murine non-small cell lung cancer (NSCLC) models, and…














