Natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists are found in food and may be important for health through their anti-inflammatory properties. Curcumin (Cur) is a bright yellow spice, derived from the rhizome of Curcuma ...
Abstract
Natural peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists are found in food and may be important for health through their anti-inflammatory properties. Curcumin (Cur) is a bright yellow spice, derived from the rhizome of Curcuma longa Linn. It has been shown to have many biological properties that appear to operate through diverse mechanisms. Some of these potentially beneficial effects of Cur are due to activation of the nuclear transcription factor PPAR-γ. It is reported (using in vitro and in vivomodels) that Cur plays a potential role against several diseases. In this review article, we present the current literature on the effects of Cur on the modulation of inflammatory processes that are mediated through PPAR-γ.
...Cur has been reported to trigger PPAR-γ but whether or not it is a ligand for it is still debated and further experimental work is required in this regard (Figure (Figure3).3). Moreover, the exact mechanisms by which Cur stimulates PPAR-γ expression are still unknown. Given the important role of Cur, there may be two ways. Cur binds to its own receptor and the complex stimulates the up-regulation of PPAR-γ, or Cur is a ligand of PPAR-γ leading to the stimulation of PPAR-γ[62,63]. A summary of the possible molecular targeting of Cur and PPAR-γ modulated by Cur is shown in Table Table1.1.