Difficult airway is the critical phase in which well-trained anesthesiologist unable to visualize any part of vocal cords facing hurdles in upper airway to ventilate the patient with facemask or with endotracheal tube to secure the patient ventilation. The aim of this study was to find out the incidence of difficult intubation and difficult laryngoscopy in diabetic patients undergoing general anesthesia. A cross sectional study was conducted at Mardan medical complex for which convenient sampling, which is a type of non-random sampling techniques, was used for collection of data from the subjects. A total 50 diabetic patients undergoing general anesthesia were preoperatively assessed for their airway manipulation using different airway indices and physical examination. Out of 50 participants, (84%) n = 42 were female and only (16%) n = 8 were male. The mean age of the subjects was 51.9 ± 11.3. After observing all the 50 participants for difficult intubation, among them (32%) n = 16 participants faced the difficult laryngoscopy while rests of the (64%) n = 34 were easily intubated. From this study, we observed that diabetic patients were more prone to difficult laryngoscopy and the only reason we found was limited mobility of the neck and less mouth opening in them. We also assumed from this study that a short term diabetic patient has no such changes in their neck mobility and mouth opening due to they were less exposed to the disease.