Dear vector prime, as the guardian of time and space what cosmic beings have you faced and defeated that have almost destroyed the transformers multiverse and timelines(besides unicorn and hytherion)?
Dear Destruction Dialoguist,
There have been many, ranging from the small to the incomprehensible, and to list them all would probably take too many of your decades, so I hope you'll understand if I limit this answer to just the one. While the Grand Uprising raged across Cybertron, a grave danger had emerged offworld—a threat neither the Protoformers or the Builders alone could address, or even comprehend.
In their distant past, during Galvatron's war with the Human Confederacy, one of the worlds caught in the crossfire was the small planet of Temptoria. To Galvatron, Temptoria was just another organic-inhabited world, fodder for his conquest, and raw materials for his Grendel Gambit—but unbeknownst to him, Temptoria had come into being around a multiversal anomaly: a living breach in the barriers between dimensions. Prior to their extinction, the Temptorians had believed it to be a mark of the creators upon the world, which they called the Brand. They used it to connect symbiotically with other realities, with "the crossover" being one of their most sacred rituals—but as centuries passed without them, the Brand grew stagnant, and fell to ruin. Dimensional instability spread from the planet, and at the epicentre, a timestorm threatened to unleash itself.
It was when the first of the anomalies reached Cybertron that I was alerted to the danger. In that reality, Blackarachnia had successfully forged an alliance with the Darksyders prior to the Vehicon Apocalypse, pushing Megatron to be bolder in his operations; during an attempt to seize Grimlock from Builder custody, they came into open conflict with Hot Rod's forces. Major Mayhem was mere moments away from tearing off Dirgegun's head, when a small group of Autobots from a distant universe spontaneously materialised in the middle of the street, towering over the Micromasters and Protoformers. To Megatron's surprise, the Autobot seemed to recognise him—and he certainly recognised the Autobot, as impossibly, it was none other than Optimus Prime!
I intervened, cutting short a potentially disastrous battle between the gathered parties by sending everyone through a dimensional gateway to Temptoria, and spoke to them about the Brand. I explained that if we didn't mend the brand, it would devour everything, reducing every universe to an endless loop of spacetime, the same events playing out eternally without development or resolution. The parcity of new information would bring about a memetic equivalent to heat death, and the Multiverse would be forever ruined. The gathered Cybertronians agreed to help me; in the case of Optimus Prime and his crew, only I could return them to their home dimension—and as for the rest, I suspect that many of them had designs of their own for the Brand. Regardless, I voiced my thanks, as it had taken a great deal of effort to bring them all together at the same time.
The situation we were faced with was undoubtedly the greatest "crossover" in history, a nightmarish unending mockery of the Temptorian's limited events. The Brand was exerting a continuous effect on other universal clusters—even ones from the greater Megaverse—taking their properties to make itself even more potent, threatening to subsume them entirely. All around us were strange beings, pulled from dimensions undreamed of, and the Brand was trying to make them part of itself, no matter how impossible that seemed, destroying itself in the process.
Hot Rod, Optimus and Megatron led their teams against these aliens, who seemed more confused than anything (I admit to being rather confused as well, especially at how many sounded similar to the Transformers). Still, it was an epic confrontation: they valiantly fought off the aliens while I saved the Brand. No sooner had I done so than the anomalies began to vanish, in the opposite order to that in which they had appeared; I had just enough time to thank Optimus Prime's crew (and answer a few lingering questions they had about one of their number's origins) before they disappeared. And, with the last of the anomalies gone, the Protoformers and Builders suddenly found themselves in the past—before they'd even set out on the mission to begin with!
I fear that the temporal trouble is why you haven't heard of this before, despite your universe's interest in the Uprising and the further adventures of Optimus Prime's team. In fact, as to whether or not the Resistance was able to overthrow their systematic oppressors in that timeline, I'm afraid I simply don't know: I myself only learned of the Protoformers' fate thanks to a spoken account of this adventure—"Cancel Culture", I believe it was called—plucked from spacetime as it settled. Such a shame it doesn't exist—I made for quite the dashing protagonist.