Mbwun, a creature from The Relic, written by Lincoln Child and Douglas Preston.
I've never seen a depiction of this guy that I was completely satisfied with. In the book, the creature was described has having "extreme posterior-anterior dimorphism", in which the front was very ape-like while the hindquarters had a lizard tail and dinosaur feet. Wrinkled face, human like eyes, possibly sparse hair.
To spoil the nineteen year old surprise ending of the book and the movie associated with the book, the creature is a result of a human being fed a certain water lily with mutagenic properties by the Kothoga, a remote civilization of people in Brazil. The idea is that the lily has a virus/reovirus within it that infect the consumer with gecko genes. The resulting mutant, the Mbwun ("He who walks on all fours") is dependant on hormones in the lily fibers in order to stay alive, and the tribe capitalizes on this, forcing the Mbwun to be their protector. The only other source of the hormone in within the human hypothalamus, and with no other option, will resort to cannibalism.
In the movie adaption of the book, the beast's name is switched with the tribe, and also possessed tiger and stag beetle genes due to the virus. This resulted in a creature that was a bit too over-designed considering what it is.
It's also a creature with a human mind, and the idea of a mutated creature that could figure out simple traps that have been set for it, be inconspicuous in it's activity, and learn "Hey, my right arm is a lot longer that my left arm, when I'm at rest I should put my weight on that one" is an interesting beast. It's described as being as fast as a greyhound, but I can't really imagine it being lithe, like a panther, but simply aware of and familiar with it's body's odd qualities and the easiest ways to make it work.
Also there's a statue of it.