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Etoposide (Drug Interaction)
In this article, we will discuss Etoposide (Drug Interaction). So, let’s get started. Warfarin: Co-administration of Etoposide with warfarin may result in elevated international normalized ratio (INR). Measure INR frequently.
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Etoposide (Hepatobiliary Disorder)
In this article, we will discuss Etoposide (Hepatobiliary disorder). So, let’s get started. Hepatobiliary disorder: hepatotoxicity
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Etoposide (Neurological Toxicity)
In this article, we will discuss Etoposide (Neurological Toxicity). So, let’s get started. Neurologic: seizure, aftertaste
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Etoposide (Skin Toxicity)
In this article, we will discuss Etoposide (Skin Toxicity). So, let’s get started. Skin: pigmentation, radiation recall dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis
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Etoposide (Respiratory Toxicity)
In this article, we will discuss Etoposide (Respiratory Toxicity). So, let’s get started. Respiratory: interstitial pneumonitis/pulmonary fibrosis
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Etoposide (Ocular Toxicity)
In this article, we will discuss Etoposide (Ocular Toxicity). So, let’s get started. Ocular: transient cortical blindness, optic neuritis.
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Etoposide (GI Toxicity)
In this article, we will discuss Etoposide (GI Toxicity). So, let’s get started. Gastrointestinal Toxicity Nausea and vomiting are the major gastrointestinal toxicities. The severity of nausea and vomiting is generally mild to moderate, with treatment discontinuation required in 1% of patients. Nausea and vomiting are managed with standard antiemetic therapy.
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Etoposide (Dosage Modifications)
In this article, we will discuss Etoposide (Dosage Modifications). So, let’s get started. Dosage Modification In patients with a creatinine clearance (CLcr) 15-50 mL/min, administer 75% of the recommended dose. Data are not available in patients with CLcr less than 15 mL/min. Consider further dose reduction in these patients.
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