Lysosomal acidity fine-tunes reactive species production in macrophages
Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis. Using platinum nanoelectrodes, researchers at Wuhan University tracked these reactive molecules in real time, revealing that lysosomal pH acts as a chemical dial. Acidic conditions favor hydrogen peroxide, while mild alkalinization promotes nitric…
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