HEADCANON: THE BLISS
A history of drug use has made it so that the Bliss found in the Henebane region of Hope County has some interesting effects on Velasquez, or the lack thereof--while in recent history he keeps mostly to smoking pot and, there have been psychedelics in his past. So, how does that affect his time in Hope County under the influence?
How Does Tolerance to Hallucinogens Effect Future Use?
Because of in-game evidence, we can safely assume that Bliss is a hallucinogenic drug made from natural ingredients. Putting this on the back burner for a moment, we should reflect on Velasquez's youth and what he'd get up to. This included and was not limited to the use of different hallucinogenic drugs, namely salvia, peyote, 'magic mushrooms' and LSD. All these substances are known to increase tolerance, thus requiring a user to take more to feel the same effects, as well as LSD affecting the body's tolerance to psilocybin. Now, how does this translate to Bliss?
There are many theories on what Bliss is, whether it's based on a real plant, and I choose to ascribe to the belief that the plant is based on Scopolamine, though clearly weaponized in the Far Cry 5 universe. This is clear in Tweak's retelling of how his family was involved in the creation of the drug. While this real plant does potentially lead to hallucinations, it's not one of the main uses, thus I believe that it's been further engineered in this game universe to behave more like other belladonna drugs.
Putting it together
So, where does that leave Velasquez? I believe it would take a much higher dose to get the desired effects with Velasquez when it comes to micro dosing and using Bliss as a mind-controlling weapon. It's possible, even, that it could only be used a handful of times before the amount needed to create the desired reaction instead causes the Angel state, or even death. In any case it's not something he enjoys, and he knows how thin the line he walks is.