Hemostatic Potential in Hypertension as a Basis Personificated Antitrimbothic Prevention and Therapy Technology
Authored by VV Udut*
The paper contains data on hemostatic potential in patients with stage 1 and stage 2 hypertension. Endothelium is a metabolic system which primarily responds to changes in homeostasis and serves as a «stabilizer» of the blood aggregate state. Hypertensive heart disease is accompanied by endothelial dysfunction manifested by vasoconstriction, increased secretion and adhesion of the hemostasis cellular system, activation of hemostasis plasma factors and, as a result, increased thrombin generation, which is the main enzyme determining the intensity of hemocoagulation. Development of endothelial dysfunction (release of the content of endothelial storage pools, contraction, and structural damage to endothelial cells with the formation of deendothelization areas and exposure of collagen fibers, etc.) contributes to the transition of hemostatic potential from hypoand normal coagulation to hypercoagulation and causes a higher risk of thrombotic complications. Therefore, are evaluation and monitoring of the hemostatic potential in therapy aimed at preventing thrombotic hemorrhagic complications great importance.
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