Image from: Francis A. Countway Library of Medicine
Article: “History of oral contraceptive drugs and their use worldwide”
The first hormonal pill was called Enovid. It was approved by the FDA in 1960. Over the years, the pill has had a lowering of Ethinyl estradiol and many different progestins.
The standard pill pack is for twenty-one days and seven days without the drugs, usually, sugar pills or they have iron to help with the blood loss.
Due to estrogen creating a high cardiovascular risk of the pill, the amount of estrogen in the pill had fifty to thirty milligrams in the sixties to an average of seventeen milligrams now. Progestin is different combined pills available nowadays, the progestin component decreases estradiol production, which thickens cervical mucus.
The initial pill was monophasic but biphasic and triphasic pills were introduced in the 1980s. They were created to decrease side effects, nausea, headaches and to mimic a women's natural cycle.
COC were first used as emergency contraception, as advised by Dr. Albert Yuzpe, obstetrician/gynecologist in 1974. In 1999 it was replaced by progestin-only emergency contraception.
Progestin-only pills been available since 1973 and are currently proposed to women who do not react well from estrogen.
In 2009, COC represented about nine percent of contraceptive use. More than 100 million women
used COCs.