#mglur5

[amcrasto]

BMS 955829

(4R,5R)-5-(2,5-difluorophenyl)-4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one (4R,5R)-5(2,5-Difluorophenyl)-4-(5-(phenylethynyl)-3-pyridinyl)-1,3-oxazolidin-2-one (4R,5R)-5-(2,5-difluorophenyl)- 4-(5-(phenylethynyl)pyridin-3-yl)oxazolidin-2-one. cas 1375751-08-8 Chemical Formula: C22H14F2N2O2 Exact Mass: 376.1023 Bristol-Myers Squibb Company INNOVATOR BMS-955829 is a Positive allosteric…

View On WordPress

[bpod-bpod]

20 October 2013

Serial Killer Blocked

The possibility of developing drugs to treat Alzheimer’s disease, the commonest form of dementia, comes closer as we unravel its complex chemistry. We know that a family of substances called amyloid-beta peptides (ABPs) is a serial killer of brain nerve cells, or neurons – whose spindly extremities vulnerable to attack are stained green in this picture of highly magnified brain tissue. While ABPs are difficult to zap with drugs, a much easier target appears to be a protein in the cell membrane, called mGluR5 which has been shown to play a critical role in the ABPs’ attack plan. In an experiment on mice with a similar condition to Alzheimer’s, their memory and learning ability were restored when mGluR5 was chemically blocked. Whether a safe and effective drug can be developed for use on humans remains to be seen but research is now underway.

Written by Mick Warwicker

—

Yale University, USA Juha Lauren and Stephen Strittmatter Research published in Neuron 79(5): 887–902