#neoantigen

[cdmoservices]

An effective anti-tumor immune response in human is marked by presence of T cells reactive against neoantigens. Neoantigens are HLA-bound unique peptides arise from tumor-specific somatic mutations. Neoantigens are highly immunogenic because they are not present in normal tissues and hence bypass central thymic tolerance.

Continue reading : https://www.aurigeneservices.com/blogs/neoantigen-specific-T-cells-for-cellular-cancer-immunotherapy

[scitechman]

NEC and VAXIMM Agree to Joint Development of Personalized Cancer Vaccine by Neoantigen

NEC and VAXIMM Agree to Joint Development of Personalized Cancer Vaccine by Neoantigen

Utilizing NEC’s state-of-the-art AI technology and VAXIMM’s original oral T-cell immunotherapy platform in joint trial agreements

NEC has decided to invest in VAXIMM

VAXIMM AG, a biotechnology company based in Switzerland and Germany, working on development of oral T-cell immunotherapy with NEC Corporation (Note 1, NEC) is based on Neoantigen. Strategic joint clinical trials and investment…

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[stojdllab]

For personalised cancer immunotherapy, multiple tumour biopsies are needed to find truly clonal neoantigen targets

http://go.nature.com/2oQzQkb

Image credit: Werner et al 2017

[stojdllab]

New algorithm predicts a tumour's total mutation load by sequencing just 170 genes

http://bit.ly/2jrpkgv Image credit: meredithwz / @flickr