Orthopaedic repair has traditionally focused on scaffolds, cells, and cytokines. But what if the true conductor of bone regeneration lies in the neuro vascular interface?
🧬 Emerging research shows that nerve-derived factors (e.g., CGRP, SP, VIP) critically regulate osteogenesis, angiogenesis, and local immune response.
📉 Could this explain why some fractures don’t heal, even when mechanically stabilized and biologically supported?
💡 It’s time to integrate neurosensory inputs into our strategies for bone and soft tissue repair.
🔬 Evidence spotlight :
Mi et al. (2021) demonstrated that calcitonin gene-related peptide (CGRP) enhances distraction osteogenesis by stimulating angiogenesis , revealing a powerful neurovascular link in bone regeneration.
Reference: Mi, J., et al. (2021). Calcitonin gene-related peptide enhances distraction osteogenesis by increasing angiogenesis.* *Tissue Engineering Part A, 27*(1-2), 87–102.
Join the growing movement at ANF Academy, where neuro-orthopedic education meets next-gen regenerative science.