We examined the effect of quercetin in relieving ischemia/reperfusion-induced liver damage using an animal model. F344 rats were divided into a control group (n=8) and a group administered 100 mg/kg of quercetin (quercetin-treated group) (n=8). Both groups underwent laparotomy, and the portal vein was ligated for 60 min to simulate ischemia. After 60 min of reperfusion, serum aspartate transaminase (AST)/alanine aminotransferase (ALT) levels, tumor necrosis factor-alpha (TNF-α) levels, and blood nitrotyrosine yield were measured. The livers were also excised to examine histology. Our results showed that AST/ALT levels, TNF-α, and nitrotyrosine yield were all significantly lower in the quercetin-treated group than in the control group. Liver damage was also significantly reduced histologically. Based on these results, administration of quercetin relieves ischemia–reperfusion-induced liver damage.