The effectiveness of lipote fruit (Syzygium currannii) pure extract for use in staining cheek cells and onion cells were studied to obtain non-toxic, environmentally friendly, and low-cost dyes for use in staining. Syzygium currannii is a small to medium-sized tree growing up to 14 meters tall. The fruit extract of Lipote has anthocyanins which are categorized as ternatins. A number of histological techniques have been identified to be used to provide a nuclear stain consisting of natural phenolic compounds, structurally related to anthocyanins. The objective of this study was to determine the effectiveness of lipote fruit extract on cheek cell and onion cell staining. Dye extracts from Syzygium currannii were used to stain cheek cells and onion cells using the existing standard staining procedures with little modification. The prepared extracts had an affinity for the cell membrane and nucleus. From the results of the Mann- Whitney U test, the stains had significant results at a P-value of 0.001413 as the highest. Therefore, this study shows that dye extracts from Syzygium currannii could be used for cheek cell and plant cell staining. Results of the stain on onion cells have the most significant result compared with the cheek cell stain results.