#osimertinib intermediate

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3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole (CAS No: 1032452-86-0) in Osimertinib Intermediates | VidgasTech

Introduction

The advancement of pharmaceutical chemistry has brought forward several innovative compounds that play a critical role in modern drug synthesis. One such compound is 3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole (CAS No: 1032452-86-0) — a vital intermediate in the preparation of Osimertinib, a targeted therapy used in the treatment of non-small cell lung cancer (NSCLC).

At VidgasTech, we specialize in the manufacturing and global supply of high-quality Osimertinib intermediates and other fine chemicals that meet stringent quality and regulatory standards.

About 3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole

Chemical Name: 3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole CAS Number: 1032452-86-0 Molecular Formula: C₁₃H₁₀ClN₃ Molecular Weight: 243.69 g/mol

This compound is one of the key intermediates required in the multi-step synthesis of Osimertinib, an EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor that specifically targets mutations associated with lung cancer resistance.

Role in Osimertinib Synthesis

Osimertinib, also known by the trade name Tagrisso, is a third-generation EGFR inhibitor developed to overcome resistance mutations such as T790M. 3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole acts as a crucial building block that contributes to the molecular structure of Osimertinib, enhancing its selectivity and potency against mutated EGFR enzymes.

This intermediate ensures synthetic efficiency and chemical stability, making it an essential part of the drug manufacturing process.

Applications

Pharmaceutical R&D: Used in the research and development of EGFR inhibitor-based therapies.

Commercial Drug Manufacturing: Serves as a key intermediate in the large-scale synthesis of Osimertinib.

Oncology Research: Supports ongoing research in targeted cancer treatments.

VidgasTech – Trusted Source for Osimertinib Intermediates

At VidgasTech, we focus on precision chemistry and quality consistency. Our manufacturing infrastructure and experienced scientific team allow us to produce 3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole and other related intermediates with high purity and reproducibility.

We ensure:

✅ Stringent quality control and analytical testing

✅ Customized synthesis based on client requirements

✅ Timely delivery and global export support

✅ Compliance with international regulatory standards

Our mission is to empower pharmaceutical companies with reliable intermediates that accelerate innovation in cancer treatment and other therapeutic areas.

Why Choose VidgasTech?

Leading manufacturer and supplier of pharmaceutical intermediates

Expertise in EGFR inhibitor chemistry and oncology intermediates

Commitment to sustainability, quality, and innovation

Strong R&D capabilities with continuous process improvement

Conclusion

3-(2-Chloropyrimidin-4-yl)-1-Methyl-1H-Indole (CAS 1032452-86-0) plays a pivotal role in the development of Osimertinib, a breakthrough in lung cancer therapy. With a strong emphasis on quality and reliability, VidgasTech continues to be a trusted partner for pharmaceutical manufacturers and research institutions worldwide.

For more details or bulk inquiries about Osimertinib intermediates, contact VidgasTech today.

Contact Information

🌐 Website: https://www.vidgastech.com

[vidgastech]

4-Fluoro-2-Methoxy-5-Nitroaniline (CAS No: 1075705-01-9): A Key Intermediate in Osimertinib Synthesis

Introduction

In the pharmaceutical industry, the importance of high-quality intermediates cannot be overstated — they form the foundation for producing life-saving drugs. One such crucial compound is 4-Fluoro-2-Methoxy-5-Nitroaniline (CAS No: 1075705-01-9), a key Osimertinib intermediate. This compound plays a vital role in the synthesis of Osimertinib, a third-generation EGFR inhibitor used to treat advanced stages of non-small cell lung cancer (NSCLC).

Among the reliable global suppliers, VidgasTech stands out as a trusted name known for manufacturing and delivering premium-grade pharmaceutical intermediates with consistent quality and purity.

Understanding 4-Fluoro-2-Methoxy-5-Nitroaniline

4-Fluoro-2-Methoxy-5-Nitroaniline is a fine chemical compound with the molecular formula C7H7FN2O3 and molecular weight 186.14 g/mol. It appears as a light yellow to brown crystalline powder and is highly valued for its role in organic synthesis, particularly in the pharmaceutical sector.

As a critical intermediate in Osimertinib synthesis, this compound contributes to the development of targeted cancer therapies that inhibit specific mutations in EGFR genes, improving the survival rates and treatment outcomes for cancer patients.

Role in Osimertinib Intermediates

Osimertinib has revolutionized the treatment of lung cancer, especially in patients resistant to earlier generations of EGFR inhibitors. The synthesis process of Osimertinib involves several key intermediates — one of the most important being 4-Fluoro-2-Methoxy-5-Nitroaniline. High-quality intermediates ensure that the final drug maintains its purity, efficacy, and safety profile, which is why sourcing this compound from a trusted manufacturer is essential.

Why Choose VidgasTech

VidgasTech is an established manufacturer and supplier of pharmaceutical intermediates, API intermediates, and fine chemicals for research and industrial applications.

Here’s what makes VidgasTech a reliable partner:

✅ Superior Purity: Every batch is produced and tested to meet international standards. ✅ Cutting-edge Manufacturing: Advanced infrastructure ensures high yield and consistent performance. ✅ Custom Synthesis: Tailored solutions based on customer specifications. ✅ Global Delivery: Fast and secure worldwide logistics. ✅ Commitment to Quality: Backed by a skilled technical team and strict quality assurance practices.

Applications

Pharmaceutical Intermediate for Osimertinib

Research and Development in Medicinal Chemistry

Fine Chemical Synthesis

About VidgasTech

VidgasTech is a leading pharmaceutical intermediate manufacturer in India, specializing in Osimertinib intermediates, API intermediates, and specialty chemicals. The company focuses on delivering reliable, high-quality chemical solutions to the global pharmaceutical industry.

For more information about 4-Fluoro-2-Methoxy-5-Nitroaniline (CAS No: 1075705-01-9) and other Osimertinib intermediates, visit: 🌐 https://www.vidgastech.com

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3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole – Osimertinib Intermediate | Vidgastech

Explore the key intermediate 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole, a vital compound in the synthesis of Osimertinib, an advanced third-generation EGFR-TKI used in lung cancer treatment. Vidgastech specializes in the manufacturing and supply of high-purity pharmaceutical intermediates, ensuring consistent quality and global standards. Our product plays a crucial role in targeted cancer therapy formulations.

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4-fluoro-2-methoxy-5- nitroaniline - vidgastech.com

Vidgastech is a reputed manufacturer and supplier of pharmaceutical intermediates, including 4-Fluoro-2-Methoxy-5-Nitroaniline, a key compound in the synthesis of Osimertinib, an EGFR inhibitor used in targeted cancer therapies. With high-purity production, global supply capabilities, and industry-standard quality control, Vidgastech supports pharma companies in delivering cutting-edge treatments.

[vidgastech]

The Role of 4-Fluoro-2-Methoxy-5-Nitroaniline in Osimertinib Intermediates: A Critical Step in Targeted Cancer Therapy

Introduction

In the evolving landscape of pharmaceutical innovation, the importance of high-purity intermediates in drug synthesis cannot be overstated. One such critical compound is 4-Fluoro-2-Methoxy-5-Nitroaniline, a key intermediate in the production of Osimertinib—a third-generation EGFR Tyrosine Kinase Inhibitor (EGFR-TKI) used in the treatment of non-small cell lung cancer (NSCLC).

At Vidgastech, we specialize in the synthesis and supply of high-quality pharmaceutical intermediates that contribute to the global effort in fighting cancer. This article highlights the significance of this compound and its role in Osimertinib synthesis.

🔬 What is 4-Fluoro-2-Methoxy-5-Nitroaniline?

Chemical Formula: C7H7FN2O3 CAS Number: [Insert if known] Appearance: Pale yellow crystalline solid Category: Pharmaceutical intermediate

4-Fluoro-2-Methoxy-5-Nitroaniline is an aromatic amine derivative that contains fluoro, methoxy, and nitro functional groups. Its structural properties make it a valuable precursor in synthesizing complex organic molecules used in targeted cancer therapies.

⚗️ Application in Osimertinib Synthesis

Osimertinib is a potent, irreversible EGFR inhibitor specifically designed to overcome resistance caused by the T790M mutation in EGFR genes. During its synthesis, 4-Fluoro-2-Methoxy-5-Nitroaniline acts as a foundational intermediate, contributing to the drug’s selectivity and potency.

Its incorporation into the molecular framework allows for enhanced binding affinity to mutant EGFR, thus improving therapeutic efficacy and minimizing off-target effects. Without this crucial intermediate, the pathway to Osimertinib’s final structure would be incomplete and inefficient.

🏭 Why Choose Vidgastech as Your Intermediate Supplier?

As a trusted name in the pharma industry, Vidgastech offers:

✅ High-purity pharmaceutical intermediates

✅ Custom synthesis and contract manufacturing

✅ Scalable production capabilities

✅ Global supply and logistics support

✅ Adherence to international regulatory standards

Whether you're a research lab or a full-scale API manufacturer, we provide tailored solutions to meet your synthesis requirements.

🌍 Conclusion

4-Fluoro-2-Methoxy-5-Nitroaniline plays a pivotal role in the successful synthesis of Osimertinib, enabling the production of life-saving cancer treatments. As demand for targeted therapies continues to rise, the need for reliable intermediate suppliers becomes more critical than ever.

Vidgastech is committed to supporting global healthcare innovation through high-quality chemical synthesis. Partner with us for your next pharmaceutical development project.

📞 Contact Information

Vidgastech 🌐 Website: www.vidgastech.com