Feb 17
Shout out to folks with Paget's Disease Of The Bone!
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Shout out to folks with Paget's Disease Of The Bone!
Paget Disease or Osteitis Deformans
Disorder in bone remodeling, 3 stages
Osteolytic (osteoclasts)
Mixed (osteclasts & osteoblasts)
Osteosclerotic (osteoblasts, “burn-out”)
Mosaic pattern on lamellar bone, big skull (no hat fits), foraminal narrowing (cranial nerve impingement), bone fractures, bone pain, warmth (increase vascularization).
Complications: AVshunt within bone marrow, can cause high output, cardiac failure, osteosarcoma
Possible underlying mechanism: Paramyxovirus infection of osteoclasts
Lab: Normal Calcium and Phosphate, INCREASED ALKALINE PHOSPHATASE