#parenchyma

[er-cryptid]

[bpod-bpod]

Fake and Kidney

Organoids are lab-grown models of tissues and organs – they give researchers the chance to poke around in ways that are impossible in the real thing. Yet growing realistic organoids is a challenge. Here tissue engineers build a 3D kidney-oid, by mimicking how the stroma (structural tissue) guides functional tissue, the parenchyma, as it develops. Watching how real kidney stroma forms, the researchers programmed mouse embryonic stem cells to follow a similar path. Combining these with parenchymal cells destined to become different parts of the kidney helps this organoid to bloom with a complex architecture. A digitised image reveals parts of its lab-grown nephron (red, white and blue) together with ureteric buds (green) which, in real kidneys, syphon liquid towards the bladder. These kidney-oids may now be used to study kidney disease or to better understand how this vital organ cleans our blood.

Written by John Ankers

Image from work by Shunsuke Tanigawa and Etsuko Tanaka, and colleagues

Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Nature Communications, February 2022

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[importantexpertbanditbagel-blog]

Canine #hepatocytes Location: #liver Characteristics and functions: #epithelialcells forming the #parenchyma of liver Shape and size: Large #polygonal cells with N:C ratio Nucleus: Round, centrally placed, compact and fine reticular chromatin(a), single #nucleolus (b), #binucleation commonly observed Cytoplasm: Eosinophilic and granular(c), some #lipofuscin pigments(d) or sometimes dark-brown black #bile Cytoarchitecture: Small clusters with pavement(e) or large clusters with trabecular morphology https://www.instagram.com/p/Bxwd3g3hyWP/?igshid=y6c5fmfnn52q

[davidtngbotany]

Transformed trees! Drought changes the plumbing system of rainforest trees

Transformed trees! Drought changes the plumbing system of rainforest trees

Trees in tropical rainforests play an important role in the water balance of the planet. Every tree is like a fountain, drawing water up from the soil and putting it out into the atnosphere.

Just one large mature tree may transpire well over 100,000 litres of water a year.

Imagine how much water a forest of trees would put out into the atmosphere, and the importance of this in maintaining the…

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[oofta-oofta]

Lungs

Lung surface area is around 100m2, with permeable low metabolic parenchyma. 

Mucociliary clearance is low in the alveoli, so drug residence time is long. And, the cell barriers are 0.1mm. This enhances the probability of absorption! Cannabis and nicotine are taken by inhalation.

[botanytoo]

Wood anatomy reveals the effects of climate change and phylogeny Although the underlying phylogeny determines the qualitative wood structure, climate has a significant influence on the functional wood anatomy of Acacia.

[fuckyeahnarcotics]

On the initial nephrogram images, a large amount of uptake was noted in the right kidney (a.k.a. prompt nephrogram); however, on the left side, there was a delay of uptake into the kidney parenchyma (a.k.a. delayed nephrogram), adelayed nephrogram is pathognomonic for an obstruction, it doesn't, however, show exactly where the obstruction is located